Department of Radiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.
Department of Radiology, Johns Hopkins University, 4940 Eastern Avenue, Baltimore, MD, 21224, USA.
J Perinatol. 2024 Aug;44(8):1119-1124. doi: 10.1038/s41372-023-01804-3. Epub 2023 Oct 20.
To evaluate whether preterm infants with prenatal opioid exposure had differences in brain size on head ultrasounds (HUS) in comparison to non-exposed infants.
Preterm infants ≤34 weeks with prenatal opioid exposure (n = 47) and matched non-exposed infants (n = 62) with early HUSs were examined. Fifteen brain measurements were made and linear regression models performed to evaluate differences.
Brain measurements were smaller in the right ventricular index [β = -0.18 mm (95% CI -0.32, -0.03]), left ventricular index [β = -0.04 mm (95% CI -0.08, -0.003)], left basal ganglia insula [β = -0.10 mm (95% CI -0.15, -0.04)], right basal ganglia insula [β = -0.08 mm (95% CI -0.14, -0.03)], corpus callosum fastigium length [β = -0.16 mm (95% CI -0.25, -0.06)], intracranial height index [β = -0.31 mm (95% CI -0.44, -0.18)], and transcerebellar measurements [β = -0.13 (95% CI -0.25, -0.02)] in the opioid-exposed group.
Preterm infants with prenatal opioid exposure have smaller brain sizes compared to non-exposed infants, potentially increasing their risk for neurodevelopmental abnormalities.
评估产前接触阿片类药物的早产儿与未接触的早产儿相比，其头部超声（HUS）的脑容量是否存在差异。
对≤34 周有产前阿片类药物暴露（n=47）的早产儿和有早期 HUS 的匹配未暴露婴儿（n=62）进行检查。测量了 15 个脑测量值，并进行线性回归模型评估差异。
右心室指数[β=-0.18mm（95%CI-0.32，-0.03）]、左心室指数[β=-0.04mm（95%CI-0.08，-0.003）]、左基底节岛叶[β=-0.10mm（95%CI-0.15，-0.04）]、右基底节岛叶[β=-0.08mm（95%CI-0.14，-0.03）]、胼胝体穹窿长度[β=-0.16mm（95%CI-0.25，-0.06）]、颅内高度指数[β=-0.31mm（95%CI-0.44，-0.18）]和颅后窝径线[β=-0.13（95%CI-0.25，-0.02）]在阿片类药物暴露组中较小。
与未暴露的婴儿相比，产前接触阿片类药物的早产儿脑容量较小，这可能增加了他们出现神经发育异常的风险。
