Department of Nephrology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China.
Department of Endocrinology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, China.
Biomed Pharmacother. 2021 Mar;135:111191. doi: 10.1016/j.biopha.2020.111191. Epub 2021 Jan 5.
Chronic kidney disease (CKD) is an increasing major public health problem worldwide. And CKD shares numerous phenotypic similarities with kidney as well as systemic ageing. Cellular senescence is mainly characterized by a stable cell cycle arrest, senescence-associated secretory phenotype (SASP) and senescent cell anti-apoptotic pathways (SCAPs). Herein, the regulations and the internal mechanisms of cellular senescence will be discussed. Meanwhile, efforts are made to give a comprehensive overview of the recent advances of the implication of cellular senescence in CKD. To date, numerous studies have focused on the effects of ageing risk factors in kidney and thereby trying to interrupt the kidney ageing processes with senolytics. Interestingly, some of them showed enormous clinical application potentials. Therefore, senotherapeutics can be applied as novel potential strategies for the treatment of CKD.
慢性肾脏病（CKD）是全球日益严重的主要公共卫生问题。CKD 与肾脏以及全身衰老具有许多表型相似性。细胞衰老主要表现为细胞周期停滞、衰老相关分泌表型（SASP）和衰老细胞抗凋亡途径（SCAPs）。本文将讨论细胞衰老的调控机制和内在机制。同时，努力对细胞衰老在 CKD 中的作用的最新进展进行全面综述。迄今为止，许多研究都集中在肾脏老化风险因素的影响上，因此试图用 senolytics 来阻断肾脏老化过程。有趣的是，其中一些显示出巨大的临床应用潜力。因此，衰老治疗可以作为治疗 CKD 的新的潜在策略。
