Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Int J Mol Sci. 2020 Dec 20;21(24):9732. doi: 10.3390/ijms21249732.
Cell adhesion ability is one of the components to establish cell organization and shows a great contribution to human body construction consisting of various types of cells mixture to orchestrate tissue specific function. The cell adhesion molecule 1 (CADM1) is a molecule of cell adhesion with multiple functions and has been identified as a tumor suppressor gene. CADM1 has multifunctions on the pathogenesis of malignancies, and other normal cells such as immune cells. However, little is known about the function of CADM1 on cutaneous cells and cutaneous malignancies. CADM1 plays an important role in connecting cells with each other, contacting cells to deliver their signal, and acting as a scaffolding molecule for other immune cells to develop their immune responses. A limited number of studies reveal the contribution of CADM1 on the development of cutaneous malignancies. Solid cutaneous malignancies, such as cutaneous squamous cell carcinoma and malignant melanoma, reduce their CADM1 expression to promote the invasion and metastasis of the tumor. On the contrary to these cutaneous solid tumors except for Merkel cell carcinoma, cutaneous lymphomas, such as adult-T cell leukemia/lymphoma, mycosis fungoides, and Sézary syndrome, increase their CADM1 expression for the development of tumor environment. Based on the role of CADM1 in the etiology of tumor development, the theory of CADM1 contribution will desirably be applied to skin tumors according to other organ malignancies, however, the characteristics of skin as a multicomponent peripheral organ should be kept in mind to conclude their prognoses.
细胞黏附能力是建立细胞组织的组成部分之一，对由各种类型的细胞混合组成的人体结构有很大的贡献，以协调组织的特定功能。细胞黏附分子 1（CADM1）是一种具有多种功能的细胞黏附分子，已被确定为一种肿瘤抑制基因。CADM1 在恶性肿瘤和其他正常细胞（如免疫细胞）的发病机制中具有多种功能。然而，人们对 CADM1 在皮肤细胞和皮肤恶性肿瘤中的功能知之甚少。CADM1 在细胞之间的连接、接触细胞传递信号以及作为其他免疫细胞发育免疫反应的支架分子方面发挥着重要作用。为数不多的研究揭示了 CADM1 在皮肤恶性肿瘤发展中的作用。皮肤实体恶性肿瘤，如皮肤鳞状细胞癌和恶性黑色素瘤，降低其 CADM1 表达以促进肿瘤的侵袭和转移。与这些皮肤实体肿瘤（除 Merkel 细胞癌外）相反，皮肤淋巴瘤，如成人 T 细胞白血病/淋巴瘤、蕈样真菌病和 Sézary 综合征，增加其 CADM1 表达以促进肿瘤微环境的发展。基于 CADM1 在肿瘤发展病因学中的作用，CADM1 贡献的理论将根据其他器官恶性肿瘤理想地应用于皮肤肿瘤，但应牢记皮肤作为多成分外围器官的特点，以得出其预后。
