Inomata H
Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Arch Ophthalmol. 1988 Feb;106(2):239-42. doi: 10.1001/archopht.1988.01060130249038.
There are various theories as to the origin of epithelioid cells in the choroid with sympathetic ophthalmia. Some investigators propose a transformation of choroidal melanocytes as the origin, and others suggest a histiomonocytic derivation. One reason this controversy exists may be the relative lack of investigations into necrotic changes of choroidal melanocytes. The structural alterations in the choroidal melanocytes of an injured eye with sympathetic ophthalmia were studied, and the sequence of events involved in degeneration and necrotic changes were elucidated. The damaged melanocytes developed vacuolation, and the melanin granules were gathered into autophagosomes or had disappeared. The nuclei of the severely damaged melanocytes became pyknotic. Degenerated cell nuclei were phagocytized by macrophages. It is concluded that choroidal melanocytes may not transform into epithelioid cells and that they disappear from the choroid following degeneration.
关于交感性眼炎脉络膜中上皮样细胞的起源有多种理论。一些研究者提出脉络膜黑素细胞的转化是其起源，另一些人则认为是组织单核细胞来源。存在这种争议的一个原因可能是对脉络膜黑素细胞坏死变化的研究相对较少。研究了交感性眼炎伤眼脉络膜黑素细胞的结构改变，并阐明了变性和坏死变化所涉及的事件顺序。受损的黑素细胞出现空泡化，黑素颗粒聚集形成自噬体或消失。严重受损的黑素细胞核固缩。变性的细胞核被巨噬细胞吞噬。得出的结论是，脉络膜黑素细胞可能不会转化为上皮样细胞，并且它们在变性后从脉络膜中消失。
