Department of Community Medicine and Rehabilitation, Umeå Universitet, Umeå, Sweden
Department of Health Sciences, Lund University, Lund, Sweden.
BMJ Open. 2021 Jan 8;11(1):e042031. doi: 10.1136/bmjopen-2020-042031.
People with anterior cruciate ligament (ACL) reconstruction (ACLR) are at high risk of sustaining a graft rupture and/or contra-lateral ACL injury. The main factors that may predispose individuals for subsequent ACL injuries are, however, not established. To reduce the risk of reinjuries, it is of particular interest to identify modifiable risk-factors, for instance, those related to sensorimotor control which are responsive to training. The aim of the current study protocol is to present the design of our prospective cohort study STOP Graft Rupture investigating sensorimotor function as predictors for graft rupture, contra-lateral ACL injury and/or failure to return to sport (RTS) within 3 years following ACLR.
We aim to recruit 200 individuals (15-35 years, ~50% women) with ACLR from Norrland University Hospital, Umeå and Lund University Hospital, Lund, Sweden. Participants will be assessed with a comprehensive test battery for sensorimotor muscle function, including hop performance, muscle strength, muscle activation, hip and ankle range of motion and postural orientation as well as patient-reported function 1 year after ACLR (baseline). For a subgroup of individuals (Umeå cohort), 3D kinematics and joint position sense will also be evaluated. At follow-up (≥3 years post-ACLR), the participants will be asked to answer questions related to new ACL injuries to either knee and about RTS. Separate logistic regression models, adjusting for possible confounders, will be used to evaluate the influence of the different sensorimotor predictors on the prospective outcomes (graft rupture, contra-lateral ACL injury, RTS).
This study was approved by the Swedish Ethical Review Board (Dnr 2016/319 and Dnr 2019-04037). The results will be published in international peer-reviewed scientific journals and presented at clinical and scientific congresses.
NCT04162613.
前交叉韧带（ACL）重建（ACLR）的患者有很高的风险发生移植物破裂和/或对侧 ACL 损伤。然而，目前尚未确定可能导致个体随后发生 ACL 损伤的主要因素。为了降低再次受伤的风险，确定可改变的危险因素（例如与感觉运动控制相关的危险因素）尤为重要，而感觉运动控制可以通过训练来改善。本研究方案的目的是介绍我们的前瞻性队列研究 STOP Graft Rupture 的设计，该研究旨在探讨感觉运动功能作为移植物破裂、对侧 ACL 损伤和/或 ACLR 后 3 年内无法重返运动（RTS）的预测因子。
我们计划从瑞典于默奥大学医院和隆德大学医院招募 200 名 ACLR 患者（15-35 岁，约 50%为女性）。参与者将接受全面的感觉运动肌肉功能测试，包括跳跃表现、肌肉力量、肌肉激活、髋关节和踝关节活动范围以及姿势定向，以及 ACLR 后 1 年的患者报告功能（基线）。对于一部分个体（于默奥队列），还将评估 3D 运动学和关节位置觉。在随访（ACL 后≥3 年）时，将要求参与者回答与双侧膝关节新 ACL 损伤和 RTS 相关的问题。将使用单独的逻辑回归模型，根据可能的混杂因素进行调整，以评估不同感觉运动预测因子对前瞻性结局（移植物破裂、对侧 ACL 损伤、RTS）的影响。
本研究已获得瑞典伦理审查委员会的批准（Dnr 2016/319 和 Dnr 2019-04037）。研究结果将发表在国际同行评议的科学期刊上，并在临床和科学大会上展示。
NCT04162613。
