Department of Periodontology, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Clin Oral Implants Res. 2021 Mar;32(3):369-381. doi: 10.1111/clr.13708. Epub 2021 Jan 28.
To evaluate new lateral bone formation and lateral volume augmentation by guided bone regeneration (GBR) in chronic non-contained bone defects with the use of a non-resorbable TiO -block.
Three buccal bone defects were created in each hemimandible of eight beagle dogs and allowed to heal for 8 weeks before treatment by GBR. Each hemimandible was randomly allocated to 4- or 12-week healing time after GBR, and three intervention groups were assigned by block randomization: TiO block: TiO -scaffold and a collagen membrane, DBBM particles: Deproteinized bovine bone mineral (DBBM) and a collagen membrane, Empty control: Collagen membrane only. Microcomputed tomography (microCT) was used to measure the lateral bone formation and width augmentation. Histological outcomes included descriptive analysis and histomorphometric measurements.
MicroCT analysis demonstrated increasing new bone formation from 4 to 12 weeks of healing. The greatest width of mineralized bone was seen in the empty controls, and the largest lateral volume augmentation was observed in the TiO block sites. The DBBM particles demonstrated more mineralized bone in the grafted area than the TiO blocks, but small amounts and less than the empty control sites.
The TiO blocks rendered the largest lateral volume augmentation but also less new bone formation compared with the DBBM particles. The most new lateral bone formation outward from the bone defect margins was observed in the empty controls, indicating that the presence of either graft material leads to slow appositional bone growth.
评估使用不可吸收的 TiO 块在慢性非包裹性骨缺损中通过引导骨再生（GBR）形成新的侧向骨形成和侧向体积增加。
在 8 只比格犬的每一半下颌骨中创建 3 个颊骨缺损，并在 GBR 治疗前允许其愈合 8 周。每一半下颌骨随机分配到 GBR 后 4 或 12 周的愈合时间，通过块随机化分配 3 个干预组：TiO 块：TiO 支架和胶原膜，DBBM 颗粒：脱蛋白牛骨矿物质（DBBM）和胶原膜，空对照：仅胶原膜。微计算机断层扫描（microCT）用于测量侧向骨形成和宽度增加。组织学结果包括描述性分析和组织形态计量学测量。
microCT 分析表明，从愈合的 4 周到 12 周，新骨形成逐渐增加。在空对照中观察到最大的矿化骨宽度，在 TiO 块部位观察到最大的侧向体积增加。DBBM 颗粒在移植物区域中显示出比 TiO 块更多的矿化骨，但数量较少，少于空对照部位。
与 DBBM 颗粒相比，TiO 块产生了最大的侧向体积增加，但新骨形成较少。在空对照中观察到从骨缺损边缘向外的新骨形成最多，表明存在任何移植物材料都会导致骨的缓慢附着生长。
