Facultad de Ingeniería Química, Universidad Autónoma de Yucatán, Mérida, Mexico.
Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico.
J Sci Food Agric. 2021 Aug 15;101(10):4193-4200. doi: 10.1002/jsfa.11057. Epub 2021 Feb 17.
Postprandial hyperglycemia and decreased insulin secretion are relevant to risk factors in the development of type 2 diabetes and its complications. Plant foods with antidiabetic properties could be an affordable alternative in the prevention and treatment of this disease. In the present study, the antihyperglycemic and hypoglycemic activity of Bixa orellana, Psidium guajava L., Cucurbita moschata, Raphanus sativus L. and Brassica oleracea var. capitata - Mayan plant foods - were evaluated at doses of 5 and 10 mg kg . Antihyperglycemic activity was measured in healthy Wistar rats and those with obesity induced by high-sucrose diet (group HSD) (20%). The hypoglycemic activity was measure in healthy CD1 mice.
Fasting glucose, Lee index and the body weight of HSD rats increased significantly (P ≤ 0.05) after 12 weeks of induction compared to healthy rats. In healthy rats, P. guajava and Bixa orellana (10 mg kg ) demonstrated higher and statistically different (P ≤ 0.05) antihyperglycemic activity compared to control acarbose (0.5 mg kg ). In the HSD rat group, all Mayan plant foods (10 mg kg ) demonstrated antihyperglycemic activity statistically equal (P ≤ 0.05) to control acarbose. However, Brassica oleracea and R. sativus registered the highest antihyperglycemic activity. Bixa orellana and P. guajava (5 mg kg ) showed similar hypoglycemic activity (P ≤ 0.05) to glibenclamide (0.5 mg kg ) but was not significant (P ≤ 0.05) compared to insulin (5 UI kg ).
The present study provides valuable evidence on the possible health benefits of Mayan plant foods. These foods could contribute to the development of therapeutic diet strategies for the prevention and treatment of diabetes. © 2021 Society of Chemical Industry.
餐后高血糖和胰岛素分泌减少与 2 型糖尿病及其并发症的发展相关的危险因素有关。具有抗糖尿病特性的植物性食物可能是预防和治疗这种疾病的一种负担得起的选择。在本研究中，评估了 Bixa orellana、Psidium guajava L.、Cucurbita moschata、Raphanus sativus L. 和 Brassica oleracea var. capitata（玛雅植物性食物）在 5 和 10mg/kg 剂量下的降血糖和降血糖活性。在健康 Wistar 大鼠和高蔗糖饮食（20%）诱导的肥胖大鼠（HSD 组）中测量抗高血糖活性。在健康 CD1 小鼠中测量降血糖活性。
与健康大鼠相比，12 周诱导后，HSD 大鼠的空腹血糖、Lee 指数和体重显著增加（P≤0.05）。在健康大鼠中，与对照阿卡波糖（0.5mg/kg）相比，Psidium guajava 和 Bixa orellana（10mg/kg）表现出更高且统计学上不同的（P≤0.05）抗高血糖活性。在 HSD 大鼠组中，所有玛雅植物性食物（10mg/kg）均表现出与对照阿卡波糖相当的抗高血糖活性（P≤0.05）。然而，Brassica oleracea 和 R. sativus 表现出最高的抗高血糖活性。Bixa orellana 和 Psidium guajava（5mg/kg）表现出与格列本脲（0.5mg/kg）相似的降血糖活性（P≤0.05），但与胰岛素（5UI/kg）相比没有统计学意义（P≤0.05）。
本研究为玛雅植物性食物的可能健康益处提供了有价值的证据。这些食物可能有助于开发治疗饮食策略，以预防和治疗糖尿病。© 2021 化学工业协会。
