芬氟拉明对肥胖糖尿病患者的代谢影响。
Metabolic effects of fenfluramine in obese diabetics.
作者信息
Larsen S, Vejtorp L, Hornnes P, Bechgaard H, Sestoft L, Lyngsoe J
出版信息
Br J Clin Pharmacol. 1977 Oct;4(5):529-33. doi: 10.1111/j.1365-2125.1977.tb00781.x.
Abstract
1 In a single-blind, cross-over study fenfluramine in a daily dose of 120 mg was found to reduce the daily blood glucose level moderately in hospitalized obese diabetics treated with a 1200 calorie diabetic diet. 2 After 7 days of treatment, fenfluramine was found not to influence the intravenous glucose tolerance, the insulin response to intravenously administered glucose, or the growth hormone response to arginine. 3 No changes in blood levels of lactate, beta hydroxybutyrate, triglycerides or cholesterol were seen during fenfluramine treatment.
摘要
- 在一项单盲交叉研究中，发现每日剂量为120毫克的芬氟拉明可使采用1200卡路里糖尿病饮食治疗的住院肥胖糖尿病患者的每日血糖水平适度降低。2. 治疗7天后，发现芬氟拉明不影响静脉葡萄糖耐量、静脉注射葡萄糖后的胰岛素反应或精氨酸后的生长激素反应。3. 在芬氟拉明治疗期间，未观察到乳酸、β-羟基丁酸、甘油三酯或胆固醇的血液水平发生变化。
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