J Biomed Nanotechnol. 2020 Oct 1;16(10):1482-1494. doi: 10.1166/jbn.2020.2984.
The combination of radiotherapy and chemotherapy is a common and useful treatment mode for tumours. But traditional methods inevitably lead to a variety of side effects. A drug delivery system (DDS), which has good biocompatibility and strong anti-tumour ability, is expected to solve this problem. Studies have shown that Ce-based nanoparticles (NPs) have good radiosensitization effect through the photoelectric effect. Hence, cisplatin-loaded LiLuF₄ :Cescintillation NPs (NP + Cis) were first constructed in this study, which was synthesized by the crystal precipitation method and characterized by transmission electron microscopy (TEM). Subsequently, its toxicity was verified, and the radiosensitization effect and basic radiosensitization mechanism on tumour cells and tumour-bearing mice were researched. Results showed that NP + Cis triggered massive DNA damage and effectively inhibited cell viability in vitro under the exposure of X-ray irradiation (IR). Moreover, the experiments in vivo showed that the NP + Cis had higher biosafety, which could absorb enough irradiation and produce a synergistic inhibitory effect on tumours through the releasing of Cis. NP + Cis can improve the performance of DDS in chemoradiotherapy.
放化疗联合是肿瘤的一种常见且有效的治疗模式。但传统方法不可避免地会导致各种副作用。药物输送系统（DDS）具有良好的生物相容性和强大的抗肿瘤能力，有望解决这一问题。研究表明，基于铈的纳米粒子（NPs）通过光电效应具有良好的放射增敏作用。因此，本研究首先构建了负载顺铂的 LiLuF₄：Cescintillation NPs（NP + Cis），通过晶体沉淀法合成，并通过透射电子显微镜（TEM）进行了表征。随后，验证了其毒性，并研究了其对肿瘤细胞和荷瘤小鼠的放射增敏作用及基本放射增敏机制。结果表明，NP + Cis 在 X 射线照射（IR）下会引发大量的 DNA 损伤，并有效抑制体外细胞活力。此外，体内实验表明，NP + Cis 具有更高的生物安全性，可通过释放 Cis 吸收足够的辐射并对肿瘤产生协同抑制作用。NP + Cis 可以提高 DDS 在放化疗中的性能。
