J Biomed Nanotechnol. 2020 Oct 1;16(10):1495-1503. doi: 10.1166/jbn.2020.2985.
The fast-growing use of supramolecular hydrogelators as biomaterials for a variety of applications, ranging from wound healing to drug delivery to tissue engineering, has highlighted the importance of synthetic design over recent years. Here, we report a new class of nanosheet stereocomplexes in aqueous solution and at physiological conditions (i. e., pH7.4), which are formed by physically mixing right- and left-handed tripeptide supramolecular hydrogelators without any external stimulus. Such tripeptides were obtained by incorporating either α-aminoisobutyric acid (Aib, U) or alanine (Ala, A) at the C-terminus or middle position of known peptide hydrogelators containing naphthalene and two phenylalanine residues. For hydrogels of these peptides, our results show that their morphologies and physical properties changed upon mixing with the L- and D-forms of the peptides forming suspension stereocomplexes. These interactions reduced molecular mobility by forming new structures with new properties and, therefore, increased the thermal stability of the compound promising for numerous medical applications.
近年来，超分子水凝胶作为生物材料在各种应用中的应用迅速发展，范围从伤口愈合到药物输送再到组织工程，这凸显了合成设计的重要性。在这里，我们报告了一类新的纳米片立体复合物，其在水溶液中和生理条件下（即 pH7.4）形成，通过将右手和左手三肽超分子水凝胶在没有任何外部刺激的情况下物理混合形成。这些三肽是通过在包含萘和两个苯丙氨酸残基的已知肽水凝胶的 C 末端或中间位置掺入α-氨基异丁酸（Aib，U）或丙氨酸（Ala，A）而获得的。对于这些肽的水凝胶，我们的结果表明，它们的形态和物理性质在与肽的 L 和 D 形式混合时发生了变化，形成了悬浮立体复合物。这些相互作用通过形成具有新性质的新结构降低了分子迁移率，从而提高了化合物的热稳定性，有望在许多医学应用中得到应用。
