Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD, 21218, USA.
Department of Materials Science and Engineering, The Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD, 21218, USA.
Adv Healthc Mater. 2019 May;8(9):e1900104. doi: 10.1002/adhm.201900104. Epub 2019 Mar 5.
Wound healing is a multifaceted biological process involving the replacement of damaged tissues and cellular structures, restoring the skin barrier's function, and maintaining internal homeostasis. Over the past two decades, numerous approaches are undertaken to improve the quality and healing rate of complex acute and chronic wounds, including synthetic and natural polymeric scaffolds, skin grafts, and supramolecular hydrogels. In this context, this review assesses the advantages and drawbacks of various types of supramolecular hydrogels including both polymeric and peptide-based hydrogels for wound healing applications. The molecular design features of natural and synthetic polymers are examined, as well as therapeutic-based and drug-free peptide hydrogels, and the strategies for each system are analyzed to integrate key elements such as biocompatibility, bioactivity, stimuli-responsiveness, site specificity, biodegradability, and clearance.
伤口愈合是一个多方面的生物学过程，涉及受损组织和细胞结构的替代，恢复皮肤屏障的功能，并维持内部的体内平衡。在过去的二十年中，人们采取了许多方法来提高复杂的急性和慢性伤口的质量和愈合率，包括合成和天然聚合物支架、皮肤移植物和超分子水凝胶。在这种情况下，本综述评估了各种类型的超分子水凝胶的优缺点，包括用于伤口愈合应用的基于聚合物和肽的水凝胶。检查了天然和合成聚合物的分子设计特点，以及基于治疗的和无药物的肽水凝胶，并且分析了每个系统的策略，以整合关键要素，如生物相容性、生物活性、刺激响应性、部位特异性、生物降解性和清除率。
