Department of Otolaryngology Head and Neck Surgery, General Hospital of Southern Theater Command of PLA (Guangzhou Liuhuaqiao Hospital), Liuhua road 111, Guangzhou 510010, Guangdong, China.
Department of Otolaryngology Head and Neck Surgery, General Hospital of Southern Theater Command of PLA (Guangzhou Liuhuaqiao Hospital), Liuhua road 111, Guangzhou 510010, Guangdong, China.
Am J Otolaryngol. 2021 Mar-Apr;42(2):102891. doi: 10.1016/j.amjoto.2020.102891. Epub 2021 Jan 4.
Cochlear microcirculation disturbance caused by vasculopathy is a common cause of sudden deafness (SD). Reactive oxygen species (ROS) plays an important role in cochlear injury during ischemia-reperfusion. Butylphthalide can improve microcirculation, reduce ROS formation and inhibit apoptosis. The aim of this study was to investigate the therapeutic effect of butylphthalide on patients with SD.
The hearing gains from 32 ears treated with butylphthalide were compared with that of 32 ears treated with non-butylphthalide. Butylphthalide capsules was administrated orally on an empty stomach for 10 continuous days. There were no significant differences in audiological and clinical data between butylphthalide and non-butylphthalide groups.
The hearing gain of butylphthalide group at 500, 1000, 2000, and 4000 Hz was significantly higher than that of non-butylphthalide group correspondingly (P<0.01). And, the hearing gain at PTA (pure-tone average of 500, 1000, 2000, and 4000 Hz) in butylphthalide group was significantly higher than that of non-butylphthalide group (P<0.01).
The recovery of hearing in butylphthalide group was significantly better than that of non-butylphthalide group. It is confirmed that butylphthalide has a definite therapeutic effect on SD.
血管病变引起的耳蜗微循环障碍是突发性聋（SD）的常见原因。活性氧（ROS）在缺血再灌注期间耳蜗损伤中起重要作用。丁基苯酞可以改善微循环，减少 ROS 形成并抑制细胞凋亡。本研究旨在探讨丁基苯酞治疗 SD 患者的疗效。
比较了 32 例使用丁基苯酞治疗的患者与 32 例使用非丁基苯酞治疗的患者的听力增益。丁基苯酞胶囊空腹口服，连续 10 天。丁基苯酞组和非丁基苯酞组在听力和临床数据方面无显著差异。
丁基苯酞组在 500、1000、2000 和 4000 Hz 时的听力增益明显高于非丁基苯酞组（P<0.01）。而且，丁基苯酞组在 PTA（500、1000、2000 和 4000 Hz 的纯音平均）时的听力增益明显高于非丁基苯酞组（P<0.01）。
丁基苯酞组的听力恢复明显优于非丁基苯酞组。证实丁基苯酞对 SD 有明确的治疗作用。
