丁基苯酞可促进突发性耳聋的恢复。

Butylphthalide enhances recovery from sudden deafness.

机构信息

Department of Otolaryngology Head and Neck Surgery, General Hospital of Southern Theater Command of PLA (Guangzhou Liuhuaqiao Hospital), Liuhua road 111, Guangzhou 510010, Guangdong, China.

出版信息

Am J Otolaryngol. 2021 Mar-Apr;42(2):102891. doi: 10.1016/j.amjoto.2020.102891. Epub 2021 Jan 4.

DOI:10.1016/j.amjoto.2020.102891

PMID:33422947

Abstract

OBJECTIVES

Cochlear microcirculation disturbance caused by vasculopathy is a common cause of sudden deafness (SD). Reactive oxygen species (ROS) plays an important role in cochlear injury during ischemia-reperfusion. Butylphthalide can improve microcirculation, reduce ROS formation and inhibit apoptosis. The aim of this study was to investigate the therapeutic effect of butylphthalide on patients with SD.

PATIENTS AND METHODS

The hearing gains from 32 ears treated with butylphthalide were compared with that of 32 ears treated with non-butylphthalide. Butylphthalide capsules was administrated orally on an empty stomach for 10 continuous days. There were no significant differences in audiological and clinical data between butylphthalide and non-butylphthalide groups.

RESULTS

The hearing gain of butylphthalide group at 500, 1000, 2000, and 4000 Hz was significantly higher than that of non-butylphthalide group correspondingly (P<0.01). And, the hearing gain at PTA (pure-tone average of 500, 1000, 2000, and 4000 Hz) in butylphthalide group was significantly higher than that of non-butylphthalide group (P<0.01).

CONCLUSION

The recovery of hearing in butylphthalide group was significantly better than that of non-butylphthalide group. It is confirmed that butylphthalide has a definite therapeutic effect on SD.

摘要