[Relationship between Serum Cystatin C and Vascular Complications in Type 2 Diabetes Mellitus Patients with Normal Renal Function].

Objective To investigate the relationship between serum cystatin C(CysC)level and vascular complications in type 2 diabetes mellitus(T2DM)patients with normal renal function. Methods Totally 218 T2DM patients who were treated in the Department of Endocrinology,Affiliated Hospital of Chengde Medical College from January 2017 to May 2018 were enrolled.All subjects were divided into four groups based on the quartiles of serum CysC levels:G1 group:≤ 0.56 mg/L,58 cases;G2 group:0.57-0.73 mg/L,52 cases;G3 group:0.74-1.11 mg/L,56 cases;G4 group:≥ 1.12 mg/L,52 cases.The general data,biochemical indicators,glycated albumin,hemoglobin Ac,CysC were compared among these four groups,and the risk of vascular complications with increasing CysC levels was analyzed. Results The carotid atherosclerosis showed significant difference between G4 group and G1 group(=-20.022, =0.001),while no statistically significant difference was seen among other groups.The risk of diabetic retinopathy was significantly higher in G3 group and G4 group than in G1 group(G3 group:=-23.827, =0.000;G4 group: =-24.576,=0.000).It was found that the risk of diabetic retinopathy significantly increased with the increase of CysC quartile compared with G1 group(G2:=3.619,95%=1.539-8.510,=0.003;G3:=5.524,95%=2.214-13.718,=0.000;G4:=5.661,95%=2.321-13.806,=0.000).Serum highest CysC level was an important risk factor for atherosclerosis(=9.842,95% =3.324-29.145,=0.000). Conclusion Serum CysC is an independent risk factor for diabetic retinopathy and carotid atherosclerosis in T2DM patients with normal renal function.