Jaworski R C, Pacey N F, Greenberg M L, Osborn R A
Department of Anatomical Pathology, Westmead Hospital, N.S.W., Australia.
Cancer. 1988 Mar 15;61(6):1171-81. doi: 10.1002/1097-0142(19880315)61:6<1171::aid-cncr2820610620>3.0.co;2-x.
Seventy-two cases of in situ adenocarcinoma (AIS) of the cervix were reviewed. Forty-five cases had associated cervical intraepithelial neoplasia and 20 cases had changes of wart virus infection. Five cases had associated microinvasive squamous cell carcinoma and one cases showed frankly invasive squamous cell carcinoma (SCC). Of the 72 cases, 41 showed an endocervical type of AIS and three cases an endometrioid type. There was no case of pure intestinal type AIS. Twenty-eight cases showed a mixed pattern. Architectural patterns characterized by tunnel clusters, cribriform glands, glandular budding and papillary formations were assessed. Most cases showed varying combinations of these patterns but in ten cases significant changes were absent. Both cellular apoptosis and mitotic activity were seen in varying degrees in all cases of AIS. The significance of these and other features of AIS are discussed as well as the conditions involved in the differential diagnosis.
回顾了72例宫颈原位腺癌（AIS）病例。45例伴有宫颈上皮内瘤变，20例有疣病毒感染改变。5例伴有微浸润性鳞状细胞癌，1例为明显浸润性鳞状细胞癌（SCC）。在这72例病例中，41例显示宫颈管型AIS，3例为子宫内膜样型。无纯肠型AIS病例。28例显示混合模式。评估了以隧道样细胞簇、筛状腺体、腺芽和乳头状结构为特征的结构模式。大多数病例显示这些模式的不同组合，但有10例无明显改变。在所有AIS病例中均可见不同程度的细胞凋亡和有丝分裂活性。讨论了AIS的这些及其他特征的意义以及鉴别诊断中涉及的情况。
