Nambisan R N, Karakousis C P, Holyoke E D, Dougherty T J
Department of Surgical Oncology, New York State Department of Health, Roswell Park Memorial Institute, Buffalo 14263.
Cancer. 1988 Mar 15;61(6):1248-52. doi: 10.1002/1097-0142(19880315)61:6<1248::aid-cncr2820610632>3.0.co;2-5.
A pilot study was done to determine the feasibility of adjuvant photodynamic therapy (PDT) in recurrent retroperitoneal sarcomas. Ten patients, who had recurrences after conventional methods of treatment, had repeated resections of the tumor and intraoperative photodynamic treatment to the tumor bed. The methods and equipment used are detailed. In eight of ten patients, a complete resection was possible, and two patients are alive without recurrence at 28 and 24 months. There were no complications from the therapy. Tumors elicited red fluorescence, which helped in identifying residual tumor areas. Adjuvant PDT is a feasible alternative although its effectiveness should be evaluated further.
开展了一项初步研究以确定辅助光动力疗法（PDT）用于复发性腹膜后肉瘤的可行性。10例经传统治疗方法后复发的患者接受了肿瘤再次切除术，并在术中对肿瘤床进行了光动力治疗。详细介绍了所使用的方法和设备。10例患者中有8例实现了完整切除，2例患者分别在28个月和24个月时存活且无复发。该治疗未引发并发症。肿瘤呈现红色荧光，这有助于识别残留肿瘤区域。辅助光动力疗法是一种可行的替代方案，不过其有效性仍需进一步评估。
