Reference Centre for Neuromuscular Disorders and ALS, CHU de La Timone, Aix-Marseille University, 264, rue Saint-Pierre, 13005 Marseille, France.
Reference Centre for Neuromuscular Disorders and ALS, CHU de La Timone, Aix-Marseille University, 264, rue Saint-Pierre, 13005 Marseille, France.
Rev Neurol (Paris). 2021 Jun;177(6):694-698. doi: 10.1016/j.neurol.2020.08.009. Epub 2021 Jan 7.
Although they are common symptoms of ALS, there is little information on the prevalence of spasticity and spasticity-related pain. Consecutive patients were prospectively recruited from an ALS referral center. Clinical assessment, functional scores, features of spasticity-related pains has been recorded. In a cohort of 150 patients, 36% presented with spasticity. Spastic patients were younger, with a longer duration of disease. Spasticity accelerates the functional decline of patients. Spasticity-related pain was reported in 42.5% of spastic patients with mild pain. However, 16.7% of spastic patients presented significant pain with numeric rating scale≥4. More clinical trials are needed to treat spasticity more effectively and to relieve ALS patients.
虽然痉挛和痉挛相关疼痛是 ALS 的常见症状，但关于其患病率的信息却很少。连续患者前瞻性地从 ALS 转诊中心招募。记录了临床评估、功能评分和痉挛相关疼痛的特征。在 150 名患者的队列中，36%的患者出现痉挛。痉挛患者更年轻，疾病持续时间更长。痉挛加速了患者的功能下降。42.5%的痉挛患者报告有轻度痉挛相关疼痛。然而，16.7%的痉挛患者出现了明显的疼痛，数字评定量表≥4。需要更多的临床试验来更有效地治疗痉挛，并减轻 ALS 患者的痛苦。
