Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Cardiovascular Research Institute of Wuhan University, Wuhan, Hubei, China.
J Interv Cardiol. 2020 Dec 21;2020:6613683. doi: 10.1155/2020/6613683. eCollection 2020.
Left atrial appendage closure (LAAC) using the LAmbre device has been associated with prevention of stroke in patients with nonvalvular atrial fibrillation (AF). Here, we interrogated the long-term safety and efficacy of using the LAmbre device in percutaneous LAAC.
We analyzed 56 records of patients with nonvalvular AF undergoing LAAC procedures with the LAmbre device. We collected and analyzed the data to define the safety and efficacy of the LAmbre device implantation.
The LAAC was successfully occluded in the 56 patients. Our data showed no serious residual leak or pericardial effusion occurred during the perioperative period. At a mean follow-up of 37.8 ± 23.5 months, there were 7.1%, 3.6%, and 3.6% rates of death, stroke, and device-related thrombus, respectively. There were no cases of severe residual leak or systemic embolism.
Taken together, we demonstrate that execution of LAAC with the LAmbre device has high procedural success and prevents AF-related stroke. However, further large-scale trials might be required to confirm our findings.
左心耳封堵（LAAC）使用 LAmbre 装置与预防非瓣膜性心房颤动（AF）患者的中风有关。在这里，我们研究了使用 LAmbre 装置进行经皮 LAAC 的长期安全性和疗效。
我们分析了 56 例接受 LAmbre 装置 LAAC 手术的非瓣膜性 AF 患者的 56 份记录。我们收集和分析数据，以确定 LAmbre 装置植入的安全性和有效性。
56 例患者的 LAAC 均成功封堵。我们的数据显示，围手术期无严重残余漏或心包积液。平均随访 37.8±23.5 个月，死亡率、中风率和器械相关血栓形成率分别为 7.1%、3.6%和 3.6%。无严重残余漏或全身栓塞病例。
综上所述，我们证明使用 LAmbre 装置进行 LAAC 具有较高的手术成功率，并可预防 AF 相关中风。然而，可能需要进一步的大规模试验来证实我们的发现。
