Calciolari G, Perlman J M, Volpe J J
Department of Pediatrics, Washington University School of Medicine, Children's Hospital, St. Louis, MO 63110.
Clin Pediatr (Phila). 1988 Mar;27(3):119-23. doi: 10.1177/000992288802700301.
A retrospective review was taken of 150 newborns with seizures evaluated at the same medical center and by the same investigator(s) from 1982 to 1987. The aims of the study were to determine in this current population the distribution of clinical seizure types, the distribution of causative etiologies, and the relation of etiology to the timing of onset of the seizures. Seizures were classified as subtle, multifocal clonic, generalized tonic, focal clonic, and myoclonic. Subtle (65% of total) and multifocal clonic seizures (54% of total) were the most common seizure types. Subtle seizures usually occurred in combination with other seizure types. Only one seizure type was related to gestational age, i.e., focal clonic seizures in the term infant. Hypoxic-ischemic encephalopathy (65% of total) was by far the most common etiology in both preterm and term infants. Seizures with hypoxic-ischemic encephalopathy occurred characteristically early in the neonatal period, i.e., 90 percent in the first 2 days of life. Moreover, 80 percent of all seizures in the first 2 days of life were related to hypoxic-ischemic encephalopathy.
对1982年至1987年期间在同一医学中心由同一研究者评估的150例惊厥新生儿进行了回顾性研究。该研究的目的是确定当前人群中临床惊厥类型的分布、病因分布以及病因与惊厥发作时间的关系。惊厥被分为细微型、多灶性阵挛型、全身性强直型、局灶性阵挛型和肌阵挛型。细微型惊厥（占总数的65%）和多灶性阵挛型惊厥（占总数的54%）是最常见的惊厥类型。细微型惊厥通常与其他惊厥类型同时出现。只有一种惊厥类型与胎龄有关，即足月儿的局灶性阵挛型惊厥。缺氧缺血性脑病（占总数的65%）是早产儿和足月儿中迄今为止最常见的病因。缺氧缺血性脑病引起的惊厥通常在新生儿期早期出现，即90%在出生后2天内出现。此外，出生后2天内所有惊厥的80%与缺氧缺血性脑病有关。
