迟发性皮肤卟啉症加重作为阴道癌的副肿瘤综合征，经放化疗后缓解。
Porphyria cutanea tarda exacerbation as a paraneoplastic syndrome in vaginal cancer resolved with chemoradiation.
作者信息
Hazell Sarah Z, Fader Amanda N, Viswanathan Akila N
机构信息
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 401 N Broadway, Suite 1440, Baltimore, MD 21287, United States.
Department of Gynecology and Obstetrics, Kelly Gynecologic Oncology Service, Johns Hopkins School of Medicine, 600 N. Wolfe St., Phipps 287, Baltimore, MD 21287, United States.
出版信息
Gynecol Oncol Rep. 2020 Dec 15;35:100682. doi: 10.1016/j.gore.2020.100682. eCollection 2021 Feb.
. The effects of therapeutic ionizing radiation in patients with PCT are not well understood. We report the case of a 55 year-old woman with a past medical history significant for kidney transplant with rejection and removal on hemodialysis, Stevens-Johnson syndrome, porphyria cutanea tarda, undifferentiated connective tissue disease probably systemic lupus, and hepatitis C, who underwent curative chemoradiation treatment for a recurrent vaginal squamous cell carcinoma. There was no increased acute toxicity and active porphyria cutanea tarda improved over the course of radiation treatment and fully resolved within 1 year. However, there was significant myofibrotic late toxicity within the treated region.
治疗性电离辐射对迟发性皮肤卟啉症（PCT）患者的影响尚未完全明确。我们报告了一名55岁女性的病例，她既往有肾移植病史，因排斥反应而移除并接受血液透析，还患有史蒂文斯-约翰逊综合征、迟发性皮肤卟啉症、可能为系统性红斑狼疮的未分化结缔组织病以及丙型肝炎，该患者因复发性阴道鳞状细胞癌接受了根治性放化疗。急性毒性未增加，活动性迟发性皮肤卟啉症在放疗过程中有所改善，并在1年内完全消退。然而，治疗区域出现了明显的肌纤维母细胞性晚期毒性。
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