Sampietro M, Fracanzani A L, Corbetta N, Amato M, Mattioli M, Molteni V, Fiorelli G, Fargion S
Department of Internal Medicine, University of Milan, IRCCS Ospedale Maggiore, Italy.
Ital J Gastroenterol Hepatol. 1997 Dec;29(6):543-7.
A strong association between sporadic porphyria cutanea tarda and chronic hepatitis C virus infection was recently described in Italy, France and Spain.
To explore whether hepatitis C virus genotype plays a role in porphyria cutanea tarda complicating chronic hepatitis C.
Forty-seven hepatitis C virus-positive porphyria cutanea tarda patients and a control group of 45 patients of similar age with hepatitis C virus-associated chronic liver disease.
Comparison of frequency of hepatitis C virus genotypes in the two groups and in relation to the age of patients, hepatic histopathology and with the presence of other factors potentially able to trigger porphyria cutanea tarda.
A single genotype, hepatitis C virus 1b, was found to be present in nearly 90% of porphyria cutanea tarda-associated chronic liver disease, significantly exceeding the frequency of the same genotype in the control group (p = 0.0001). The presence of hepatitis C virus 1b was not related to the age of patients or disease severity as evaluated by hepatic histopathology.
Hepatitis C virus-associated chronic hepatitis found in the majority of Italian patients with porphyria cutanea tarda is usually sustained by hepatitis C virus genotype 1b. This viral strain might have a direct pathogenic role in inducing porphyria cutanea tarda or could increase the susceptibility of patients of other triggering factors such as iron overload or alcohol abuse.
近期在意大利、法国和西班牙发现散发性迟发性皮肤卟啉症与慢性丙型肝炎病毒感染之间存在密切关联。
探讨丙型肝炎病毒基因型在迟发性皮肤卟啉症合并慢性丙型肝炎中是否起作用。
47例丙型肝炎病毒阳性的迟发性皮肤卟啉症患者以及45例年龄相仿的丙型肝炎病毒相关慢性肝病患者组成的对照组。
比较两组中丙型肝炎病毒基因型的频率，并与患者年龄、肝脏组织病理学以及其他可能引发迟发性皮肤卟啉症的因素进行关联分析。
发现单一基因型丙型肝炎病毒1b存在于近90%的迟发性皮肤卟啉症相关慢性肝病中，显著高于对照组中该基因型的频率（p = 0.0001）。丙型肝炎病毒1b的存在与患者年龄或肝脏组织病理学评估的疾病严重程度无关。
在大多数意大利迟发性皮肤卟啉症患者中发现的丙型肝炎病毒相关慢性肝炎通常由丙型肝炎病毒基因型1b引起。这种病毒株可能在诱发迟发性皮肤卟啉症中具有直接致病作用，或者可能增加患者对其他触发因素如铁过载或酒精滥用的易感性。
