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Role of PI3K/Akt/GSK-3 Pathway in Emesis and Potential New Antiemetics.

作者信息

Zhong W, Darmani N A

机构信息

Department of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USA.

出版信息

J Cell Signal. 2020 Dec;1(4):155-159. doi: 10.33696/Signaling.1.024.

DOI:10.33696/Signaling.1.024
PMID:33426544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7793561/
Abstract
摘要

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1
The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva).糖原合酶激酶 3（GSK-3）在小臭鼩（Cryptotis parva）对特定催吐物引发呕吐中的关键作用。
Neurochem Int. 2020 Jan;132:104603. doi: 10.1016/j.neuint.2019.104603. Epub 2019 Nov 15.
2
Management of toxicity to isoform α-specific PI3K inhibitors.α 型特异性 PI3K 抑制剂毒性的管理。
Ann Oncol. 2019 Dec 1;30(Suppl_10):x21-x26. doi: 10.1093/annonc/mdz440.
3
mTOR: Role in cancer, metastasis and drug resistance.mTOR：在癌症、转移和耐药性中的作用。
Semin Cancer Biol. 2019 Dec;59:92-111. doi: 10.1016/j.semcancer.2019.07.003. Epub 2019 Aug 10.
4
Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses.糖原合酶激酶-3β抑制剂作为新型癌症治疗药物和抗肿瘤免疫反应调节剂。
Cancer Biol Ther. 2019;20(8):1047-1056. doi: 10.1080/15384047.2019.1595283. Epub 2019 Apr 12.
5
The relation between PI3K/AKT signalling pathway and cancer.PI3K/AKT 信号通路与癌症的关系。
Gene. 2019 May 25;698:120-128. doi: 10.1016/j.gene.2019.02.076. Epub 2019 Mar 5.
6
Roles of PI3K/AKT/GSK3 Pathway Involved in Psychiatric Illnesses.PI3K/AKT/GSK3信号通路在精神疾病中的作用
Diseases. 2019 Feb 13;7(1):22. doi: 10.3390/diseases7010022.
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Intracellular emetic signaling cascades by which the selective neurokinin type 1 receptor (NKR) agonist GR73632 evokes vomiting in the least shrew (Cryptotis parva).选择性神经激肽 1 型受体（NKR）激动剂 GR73632 引起最小鼩鼱（Cryptotis parva）呕吐的细胞内催吐信号级联。
Neurochem Int. 2019 Jan;122:106-119. doi: 10.1016/j.neuint.2018.11.012. Epub 2018 Nov 16.
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Biochim Biophys Acta Rev Cancer. 2018 Dec;1870(2):185-197. doi: 10.1016/j.bbcan.2018.08.001. Epub 2018 Aug 21.
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