Buccheri G, Ferrigno D
A. Carle Hospital of Chest Diseases, Medical Departments, Cuneo, Italy.
Chest. 1988 Mar;93(3):565-70. doi: 10.1378/chest.93.3.565.
A study of tissue polypeptide antigen (TPA) serum levels was conducted in patients with various cell types of bronchial carcinoma. A total of 548 assays (226 pretreatment) were evaluated. In all, the sensitivity of the test at diagnosis was 61 percent. It varied considerably in relation to the extent and site of disease. Individual pretreatment values of TPA correlated significantly with the stage of disease. Similarly, posttreatment TPA values related to disease evolution. In small cell carcinoma, eight of the 29 meaningful changes in follow-up levels of TPA preceded clinical recognition of disease status variations. Raised pretreatment values of TPA were significantly associated with a shortened survival. These results indicate that TPA may contribute to staging, monitoring, and prognosis of lung cancer.
对不同细胞类型支气管癌患者的组织多肽抗原（TPA）血清水平进行了一项研究。共评估了548次检测（226次为治疗前检测）。总体而言，该检测在诊断时的敏感性为61%。其敏感性因疾病范围和部位的不同而有很大差异。TPA的个体治疗前值与疾病分期显著相关。同样，治疗后TPA值与疾病进展相关。在小细胞癌中，TPA随访水平有意义的29次变化中有8次先于疾病状态变化的临床识别。TPA治疗前值升高与生存期缩短显著相关。这些结果表明，TPA可能有助于肺癌的分期、监测和预后评估。
