2 型糖尿病患者的工作能力相关骨骼肌蛋白发生改变——10-20-30 训练的影响。
Skeletal muscle proteins important for work capacity are altered with type 2 diabetes - Effect of 10-20-30 training.
机构信息
Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
出版信息
Physiol Rep. 2021 Jan;9(1):e14681. doi: 10.14814/phy2.14681.
The study examined whether men with type 2 diabetes exhibit lower expression of muscle proteins important for exercise capacity, and whether exercise training promotes adaptations in these proteins. In a cross-sectional and longitudinal study, conducted at the University of Copenhagen. Twelve men with type 2 diabetes (T2D) were compared to eleven nondiabetes counterparts (ND) matched for age and body composition (body fat percentage). T2D underwent 10 weeks of high-intensity interval exercise training (10-20-30 training). T2D had lower expression of SOD1 (-62%; p < 0.001) and ETC complex V (-34%; p = 0.003), along with higher expression of ETC complex IV (+66%; p = 0.007), MFN2 (+62%; p = 0.001), and DRP1 (+30%; p = 0.028) compared to ND. T2D had higher (p < 0.001) expression of Na /K α1 (+98%), α2 (+114%), and NHE1 (+144%) than ND. In T2D, training increased exercise capacity (+9%; p < 0.001) as well as expression of SOD2 (+44%; p = 0.029), ETC complex II (+25%; p = 0.035), III (+52%; p = 0.041), IV (+23%; p = 0.005), and V (+21%; p = 0.035), CS activity (+32%; p = 0.006) as well as Na /K α1 (+24%; p = 0.034), Kir6.2 (+36%; p = 0.029), and MCT1 (+20%; p = 0.007). Men with type 2 diabetes exhibited altered expression of a multitude of skeletal muscle proteins important for exercise capacity. Ten weeks of 10-20-30 training upregulated expression of muscle proteins regulating antioxidant defense, mitochondrial function, and ion handling while enhancing exercise capacity in men with type 2 diabetes.
这项研究旨在探讨 2 型糖尿病男性是否表现出与运动能力相关的肌肉蛋白表达降低，以及运动训练是否会促进这些蛋白的适应性改变。该研究在哥本哈根大学进行，采用横断面和纵向研究设计，比较了 12 名 2 型糖尿病（T2D）男性与 11 名年龄和体脂百分比相匹配的非糖尿病对照者（ND）。T2D 患者接受了 10 周的高强度间歇训练（10-20-30 训练）。与 ND 相比，T2D 患者的 SOD1 表达降低了 62%（p < 0.001），ETC 复合物 V 表达降低了 34%（p = 0.003），而 ETC 复合物 IV 表达增加了 66%（p = 0.007），MFN2 表达增加了 62%（p = 0.001），DRP1 表达增加了 30%（p = 0.028）。T2D 患者的 Na+/K+α1 表达（p < 0.001）增加了 98%，α2 增加了 114%，NHE1 增加了 144%。在 T2D 患者中，训练使运动能力提高了 9%（p < 0.001），同时 SOD2 表达增加了 44%（p = 0.029），ETC 复合物 II 表达增加了 25%（p = 0.035），III 表达增加了 52%（p = 0.041），IV 表达增加了 23%（p = 0.005），V 表达增加了 21%（p = 0.035），CS 活性增加了 32%（p = 0.006），Na+/K+α1 表达增加了 24%（p = 0.034），Kir6.2 表达增加了 36%（p = 0.029），MCT1 表达增加了 20%（p = 0.007）。2 型糖尿病男性表现出与运动能力相关的多种骨骼肌蛋白表达改变。10 周的 10-20-30 训练上调了调节抗氧化防御、线粒体功能和离子处理的肌肉蛋白表达，同时提高了 2 型糖尿病男性的运动能力。
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