Renal Division, Department of Medicine, Peking University First Hospital, Beijing, People's Republic of China.
Renal Pathology Center, Institute of Nephrology, Peking University, Beijing, People's Republic of China.
J Nephrol. 2021 Oct;34(5):1669-1672. doi: 10.1007/s40620-020-00894-y. Epub 2021 Jan 4.
We report a young woman presented with nephrotic syndrome and normotension during every pregnancy and achieved complete remissions after the deliveries. We thus inferred that her nephrotic syndrome was closely associated with pregnancy. Kidney biopsies were perfromed and showed different histologic patterns: the first biopsy showed a pattern of endocapillary proliferative glomerulonephritis; the second biopsy revealed proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) with features of membranous nephropathy. With regard to presentation during the second trimester of pregnancy, achieving complete remission after delivery, and no relapse during the follow-up period, pregnancy associated PGNMID is suggested. To our best knowledge, this is the first reported case of PGNMID associated with pregnancy.
我们报告了一位年轻女性，她在每次怀孕期间均表现为肾病综合征和血压正常，并在分娩后完全缓解。因此，我们推断她的肾病综合征与妊娠密切相关。进行了肾脏活检，显示出不同的组织学模式：第一次活检显示出毛细血管内增生性肾小球肾炎的模式；第二次活检显示出伴有单克隆免疫球蛋白沉积的增生性肾小球肾炎（PGNMID），具有膜性肾病的特征。鉴于第二次妊娠中期的表现、分娩后完全缓解以及随访期间无复发，提示与妊娠相关的 PGNMID。据我们所知，这是首例与妊娠相关的 PGNMID 报道。
