嗜热栖热放线菌中通过C5途径由谷氨酸生成5-氨基乙酰丙酸。
5-Aminolevulinic acid formation from glutamate via the C5 pathway in Clostridium thermoaceticum.
作者信息
Oh-hama T, Stolowich N J, Scott A I
机构信息
Department of Chemistry, Texas A&M University, College Station 77843.
出版信息
FEBS Lett. 1988 Feb 8;228(1):89-93. doi: 10.1016/0014-5793(88)80591-x.
PMID:3342879
Abstract
A cell-free extract of the anaerobic eubacterium, Clostridium thermoaceticum, catalyzes the synthesis of 5-aminolevulinic acid (ALA) from glutamate via the C5 pathway. The enzyme reaction resembles that of higher plants and algae in cofactor requirements and sensitivity to ribonuclease. From the phylogenetic distribution it is proposed that the C5 pathway evolved earlier than the ALA synthase pathway.
摘要
厌氧真细菌热醋梭菌的无细胞提取物通过C5途径催化由谷氨酸合成5-氨基乙酰丙酸（ALA）。该酶反应在辅因子需求和对核糖核酸酶的敏感性方面类似于高等植物和藻类。从系统发育分布来看，有人提出C5途径比ALA合酶途径进化得更早。
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