新铜试剂、1,10-菲啰啉和2,2'-联吡啶与人铜蓝蛋白的相互作用。
Interaction of neocuproine, 1,10-phenanthroline and 2,2'-dipyridyl with human ceruloplasmin.
作者信息
Løvstad R A
机构信息
Institute of Medical Biochemistry, University of Oslo, Norway.
出版信息
Int J Biochem. 1988;20(1):117-9. doi: 10.1016/0020-711x(88)90022-5.
PMID:3342923
Abstract
- Neocuproine binding to ceruloplasmin markedly increases the chlorpromazine-ceruloplasmin-catalyzed oxidation of NADH. 2. 1,10-Phenanthroline and 2,2'-dipyridyl inhibit neocuproine activation in a competitive manner. 3. The order of enzyme chelator complex stability was: phenanthroline greater than dipyridyl greater than neocuproine.
摘要
- 新铜试剂与铜蓝蛋白结合显著增强了氯丙嗪 - 铜蓝蛋白催化的NADH氧化反应。2. 1,10 - 菲啰啉和2,2'-联吡啶以竞争性方式抑制新铜试剂的活化。3. 酶 - 螯合剂复合物稳定性顺序为：菲啰啉大于联吡啶大于新铜试剂。
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