Mazigi Ohan, Kannan M Bobby, Xu Jia, Choe Han-Cheol, Ye Qingsong
Biomaterials and Engineering Materials (BEM) Laboratory College of Science and Engineering, James Cook University, 1 James Cook Drive, Townsville, Queensland 4811, Australia.
College of Medicine and Dentistry, James Cook University, 14-88 McGregor Road, Cairns, Queensland 4878, Australia.
ACS Biomater Sci Eng. 2017 Apr 10;3(4):509-517. doi: 10.1021/acsbiomaterials.6b00563. Epub 2017 Mar 6.
In this study, the biocompatibility and degradation behavior of a low elastic modulus Ti-35Nb-3Zr alloy were investigated and compared with that of the conventional orthopedic and dental implant materials, i.e., commercially pure titanium (Cp-Ti) and Ti-6Al-4V alloy. The biocompatibility test results suggested that cells proliferate equally well on Ti-35Nb-3Zr and Cp-Ti. The degradation rates of Cp-Ti and Ti-6Al-4V were ∼68% ( < 0.05) and ∼84% ( < 0.05) lower as compared to Ti-35Nb-3Zr, respectively. Interestingly, the passive current density (i) of the Ti-35Nb-3Zr alloy was ∼29% lower than that of Cp-Ti, which suggests that the alloying elements in the Ti-35Nb-3Zr alloy have contributed to its passivation behavior. Nanosurface engineering of the Ti-35Nb-3Zr alloy, i.e., a two-step electrochemical process involving anodization (producing nanoporous layer) and calcium phosphate (CaP) deposition, decreased the degradation rate of the alloy by ∼83% ( < 0.05), and notably, it was similar to the conventional Ti-6Al-4V alloy. Hence, it can be suggested that the nanosurface-engineered low elastic modulus Ti-35Nb-3Zr alloy is a promising material for orthopedic and dental implant applications.
在本研究中，对一种低弹性模量Ti-35Nb-3Zr合金的生物相容性和降解行为进行了研究，并与传统的骨科和牙科植入材料，即商业纯钛（Cp-Ti）和Ti-6Al-4V合金进行了比较。生物相容性测试结果表明，细胞在Ti-35Nb-3Zr和Cp-Ti上的增殖情况相同。与Ti-35Nb-3Zr相比，Cp-Ti和Ti-6Al-4V的降解率分别低约68%（<0.05）和约84%（<0.05）。有趣的是，Ti-35Nb-3Zr合金的静态电流密度（i）比Cp-Ti低约29%，这表明Ti-35Nb-3Zr合金中的合金元素有助于其钝化行为。Ti-35Nb-3Zr合金的纳米表面工程，即涉及阳极氧化（产生纳米多孔层）和磷酸钙（CaP）沉积的两步电化学过程，使合金的降解率降低了约83%（<0.05），值得注意的是，它与传统的Ti-6Al-4V合金相似。因此，可以认为纳米表面工程化的低弹性模量Ti-35Nb-3Zr合金是一种有前途的骨科和牙科植入应用材料。
