Department of Chemical and Metallurgical Engineering, School of Chemical Engineering, Aalto University Foundation, 02150, Espoo, Finland.
Sci Rep. 2023 Feb 9;13(1):2312. doi: 10.1038/s41598-023-29553-5.
The performance of current biomedical titanium alloys is limited by inflammatory and severe inflammatory conditions after implantation. In this study, a novel Ti-Nb-Zr-Si (TNZS) alloy was developed and compared with commercially pure titanium, and Ti-6Al-4V alloy. Electrochemical parameters of specimens were monitored during 1 h and 12 h immersion in phosphate buffered saline (PBS) as a normal, PBS/hydrogen peroxide (HO) as an inflammatory, and PBS/HO/albumin/lactate as a severe inflammatory media. The results showed an effect of the HO in inflammatory condition and the synergistic behavior of HO, albumin, and lactate in severe inflammatory condition towards decreasing the corrosion resistance of titanium biomaterials. Electrochemical tests revealed a superior corrosion resistance of the TNZS in all conditions due to the presence of silicide phases. The developed TNZS was tested for subsequent cell culture investigation to understand its biocompatibility nature. It exhibited favorable cell-materials interactions in vitro compared with Ti-6Al-4V. The results suggest that TNZS alloy might be a competitive biomaterial for orthopedic applications.
当前的生物医学钛合金的性能受到植入后炎症和严重炎症条件的限制。在这项研究中，开发了一种新型 Ti-Nb-Zr-Si（TNZS）合金，并将其与纯钛和 Ti-6Al-4V 合金进行了比较。将样品在磷酸盐缓冲盐水（PBS）中浸泡 1 小时和 12 小时期间的电化学参数进行了监测，作为正常条件、PBS/过氧化氢（HO）作为炎症条件和 PBS/HO/白蛋白/乳酸作为严重炎症条件下的条件。结果表明，HO 在炎症条件下具有作用，并且在严重炎症条件下，HO、白蛋白和乳酸具有协同作用，这会降低钛生物材料的耐腐蚀性。电化学测试表明，由于存在硅化物相，TNZS 在所有条件下都具有优异的耐腐蚀性。开发的 TNZS 进行了后续的细胞培养研究，以了解其生物相容性。与 Ti-6Al-4V 相比，它在体外表现出良好的细胞-材料相互作用。结果表明，TNZS 合金可能是一种用于骨科应用的有竞争力的生物材料。
