Department of Rehabilitation, The First Hospital of Lanzhou University.
Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou City, Gansu Province.
Medicine (Baltimore). 2021 Jan 8;100(1):e23945. doi: 10.1097/MD.0000000000023945.
Alzheimer disease (AD) is a progressive neurodegenerative disease characterized by impaired memory and cognitive judgment. It is the leading cause of dementia in the elderly, and its high morbidity and mortality have also brought a significant social burden. So far, there is no method can completely cure Alzheimer's dementia, but there are many non-drug treatments that have been praised by people, especially the cognitive behavioral therapy proposed in recent years. The main purpose of this article is to evaluate the effect of cognitive behavioral therapy on the cognitive function improvement of patients with Alzheimer's dementia.
We did a network meta-analysis to identify both direct and indirect evidence in relevant studies. A systematic literature search will be performed in the Cochrane Library, PubMed, and EMBASE from inception to October 2020. We extracted the relevant information from these trials with a predefined data extraction sheet and assessed the risk of bias with the Cochrane risk of bias tool.The outcomes investigated were Mini-Mental State Examination and AD Assessment Scale-Cognitive section scores. We did a pair-wise meta-analysis using the fixed-effects model and then did a random-effects network meta-analysis within a Bayesian framework. The = the Assessment of Multiple Systematic Reviews-2 scale, Preferred Reporting Items for Systematic Reviews and Meta-Analyses scale and Grading of Recommendations Assessment, Development and Evaluation were used to assess the quality and evidence grade of the literature. General characteristics of the eligible randomized controlled trials will be summarized and described. Meanwhile, The ADDIS software will be used to perform the network meta-analysis, and the result figures will be generated by STATA 15.0 software.
Using the draft search strategy of databases and after screening,7 randomized controlled trials met the a priori criteria and were included. This network mate-analysis will be published in a peer-reviewed journal.
Our study will provide evidence for cognitive behavioral intervention in AD patients. And provide recommendations and guidelines for the clinic.
INPLASY2020110052.
阿尔茨海默病（AD）是一种进行性神经退行性疾病，其特征是记忆和认知判断受损。它是老年人痴呆症的主要原因，其高发病率和死亡率也带来了巨大的社会负担。到目前为止，尚无方法可以完全治愈阿尔茨海默病痴呆症，但有许多非药物治疗方法受到人们的称赞，尤其是近年来提出的认知行为疗法。本文的主要目的是评估认知行为疗法对阿尔茨海默病患者认知功能改善的效果。
我们进行了网络荟萃分析，以确定相关研究中的直接和间接证据。从成立到 2020 年 10 月，我们将在 Cochrane 图书馆、PubMed 和 EMBASE 中进行系统文献检索。我们使用预定义的数据提取表从这些试验中提取相关信息，并使用 Cochrane 偏倚风险工具评估偏倚风险。研究的结果是采用简易精神状态检查表和阿尔茨海默病评估量表-认知部分评分。我们使用固定效应模型进行了两两荟萃分析，然后在贝叶斯框架内进行了随机效应网络荟萃分析。使用评估多个系统评价-2 量表、系统评价和荟萃分析报告的首选项目和推荐评估、发展和评估分级来评估文献的质量和证据等级。将总结和描述合格的随机对照试验的一般特征。同时，将使用 ADDIS 软件进行网络荟萃分析，并使用 STATA 15.0 软件生成结果图。
使用数据库的草案搜索策略并经过筛选后，有 7 项随机对照试验符合预先设定的标准并被纳入。本网络荟萃分析将发表在同行评议的期刊上。
我们的研究将为 AD 患者的认知行为干预提供证据，并为临床提供建议和指导。
INPLASY2020110052。
