Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, AQ, Italy.
Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Philadelphia, PA 19122, USA.
Mar Drugs. 2021 Jan 8;19(1):24. doi: 10.3390/md19010024.
Marine habitats offer a rich reservoir of new bioactive compounds with great pharmaceutical potential; the variety of these molecules is unique, and its production is favored by the chemical and physical conditions of the sea. It is known that marine organisms can synthesize bioactive molecules to survive from atypical environmental conditions, such as oxidative stress, photodynamic damage, and extreme temperature. Recent evidence proposed a beneficial role of these compounds for human health. In particular, xanthines, bryostatin, and 11-dehydrosinulariolide displayed encouraging neuroprotective effects in neurodegenerative disorders. This review will focus on the most promising marine drugs' neuroprotective potential for neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases. We will describe these marine compounds' potential as adjuvant therapies for neurodegenerative diseases, based on their antioxidant, anti-inflammatory, and anti-apoptotic properties.
海洋生境提供了丰富的新生物活性化合物资源，具有巨大的药物潜力；这些分子的多样性是独特的，其产生受到海洋化学和物理条件的青睐。众所周知，海洋生物可以合成生物活性分子，以适应非典型的环境条件，如氧化应激、光动力损伤和极端温度。最近的证据表明，这些化合物对人类健康有有益的作用。特别是黄嘌呤、海鞘素和 11-脱水辛可尼定在神经退行性疾病中表现出令人鼓舞的神经保护作用。本综述将重点介绍最有前途的海洋药物对神经退行性疾病（如帕金森病和阿尔茨海默病）的神经保护潜力。我们将根据这些海洋化合物的抗氧化、抗炎和抗细胞凋亡特性，描述它们作为神经退行性疾病辅助治疗的潜力。
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