Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
Neurochem Res. 2022 Oct;47(10):2954-2962. doi: 10.1007/s11064-022-03667-0. Epub 2022 Jul 8.
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases worldwide. They are characterized by the loss of neurons and synapses in special parts of the central nervous system (CNS). There is no definitive treatment for AD and PD, but extensive studies are underway to identify the effective drugs which can slow the progression of these diseases by affecting the factors involved in their pathophysiology (i.e., aggregated proteins, neuroinflammation, and oxidative stress). Icariin, a natural compound isolated from Epimedii herba, is known because of its anti-inflammatory and anti-oxidant properties. In this regard, there are numerous studies indicating its potential as a natural compound against the progression of CNS disorders, such as neurodegenerative diseases. Therefore, this review aims to re-examine findings on the pharmacologic effects of icariin on factors involved in the pathophysiology of AD and PD.
阿尔茨海默病（AD）和帕金森病（PD）是全球最常见的神经退行性疾病。它们的特征是中枢神经系统（CNS）特定部位的神经元和突触丧失。目前尚无针对 AD 和 PD 的明确治疗方法，但正在进行广泛的研究，以确定有效的药物，通过影响其病理生理学中涉及的因素（即聚集蛋白、神经炎症和氧化应激）来减缓这些疾病的进展。淫羊藿素是从淫羊藿中分离出来的一种天然化合物，以其抗炎和抗氧化特性而闻名。在这方面，有大量研究表明它具有作为一种天然化合物来对抗 CNS 疾病（如神经退行性疾病）进展的潜力。因此，本综述旨在重新审视淫羊藿素对 AD 和 PD 病理生理学中涉及的因素的药理作用的研究结果。
