Gaston Jordan R, Johnson Alexandra O, Bair Kirsten L, White Ashley N, Armbruster Chelsie E
Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo.
Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo.
Infect Immun. 2021 Jan 11. doi: 10.1128/IAI.00652-20.
The vast majority of research pertaining to urinary tract infection has focused on a single pathogen in isolation, and predominantly However, polymicrobial urine colonization and infection are prevalent in several patient populations, including individuals with urinary catheters. The progression from asymptomatic colonization to symptomatic infection and severe disease is likely shaped by interactions between traditional pathogens as well as constituents of the normal urinary microbiota. Recent studies have begun to experimentally dissect the contribution of polymicrobial interactions to disease outcomes in the urinary tract, including their role in development of antimicrobial-resistant biofilm communities, modulating the innate immune response, tissue damage, and sepsis. This review aims to summarize the epidemiology of polymicrobial urine colonization, provide an overview of common urinary tract pathogens, and present key microbe-microbe and host-microbe interactions that influence infection progression, persistence, and severity.
绝大多数与尿路感染相关的研究都集中在单一病原体上，且主要是孤立地研究。然而，多种微生物在尿液中的定植和感染在包括留置导尿管的个体在内的多个患者群体中很普遍。从无症状定植到有症状感染及严重疾病的进展可能受到传统病原体以及正常泌尿微生物群成分之间相互作用的影响。最近的研究已开始通过实验剖析多种微生物相互作用对尿路疾病结局的影响，包括它们在耐抗菌生物膜群落形成、调节先天免疫反应、组织损伤和败血症中的作用。本综述旨在总结多种微生物在尿液中定植的流行病学，概述常见的尿路病原体，并介绍影响感染进展、持续和严重程度的关键微生物-微生物以及宿主-微生物相互作用。
