Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
Sci Rep. 2021 Jan 11;11(1):269. doi: 10.1038/s41598-020-79540-3.
Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to create an optimized anatomical brain template and accompanying MWF and IET2 atlases. We then used the MWF atlas to characterize how myelin content relates to demographic factors. In most brain regions, myelin content followed a quadratic pattern of increase during the third decade of life, plateau at a maximum around the fifth decade, then decrease during later decades. The ranking of mean myelin content between brain regions remained consistent across age groups. These openly available normative atlases can facilitate evaluation of myelin imaging results on an individual basis and elucidate the distribution of myelin content between brain regions and in the context of aging.
髓鞘水成像是一种定量神经影像学技术，可提供髓鞘水分数 (MWF)，这是一种高度特定于髓鞘含量的指标，以及细胞内/细胞外 T (IET2)，它与水和铁含量有关。我们结合了 100 名成年人的高分辨率数据和黄金标准方法，创建了一个优化的解剖大脑模板以及配套的 MWF 和 IET2 图谱。然后，我们使用 MWF 图谱来描述髓鞘含量与人口统计学因素的关系。在大多数大脑区域中，髓鞘含量在生命的第三个十年呈二次增长模式，在第五个十年左右达到最大值，然后在以后的几十年中下降。脑区之间平均髓鞘含量的排序在不同年龄组之间保持一致。这些公开可用的规范图谱可以促进基于个体的髓鞘成像结果的评估，并阐明脑区之间以及随年龄变化的髓鞘含量的分布。
