Department of Pharmacy & Biotechnology, University of Bologna, 40126 Bologna, Italy.
Sarcoma Translational Research Laboratory, Vall d'Hebron Institute of Oncology, 08035 Barcelona, Spain.
Epigenomics. 2021 Mar;13(5):369-377. doi: 10.2217/epi-2020-0303. Epub 2021 Jan 12.
Gastrointestinal stromal tumor management is extremely challenging, particularly the metastatic disease. The underlying mechanism in metastasis spread remains largely unknown. We aimed to characterize miRNAs involved in the metastatic process in gastrointestinal stromal tumor. Eight primary tumors and 18 synchronous metastases were analyzed through miRNA Taqman arrays or assays. miRNAs profiles revealed similar expression in primary site and metastases. Pair-wise correlation coefficient between primary tumor and metastases was significant for each patient (p < 0.0001 for all profiled patients). Our study, the largest including primary tumors and metastases so far performed, highlighted perpetuation of miRNAs features in metastatic lesions and that the primary origin appears to be the main determinant of the metastases miRNA profile.
胃肠道间质瘤的治疗极具挑战性，尤其是转移性疾病。转移扩散的潜在机制在很大程度上仍然未知。我们旨在描述胃肠道间质瘤转移过程中涉及的 miRNAs。通过 miRNA Taqman 微阵列或检测分析了 8 个原发肿瘤和 18 个同步转移灶。miRNA 谱显示原发灶和转移灶的表达相似。每个患者的原发肿瘤与转移灶之间的成对相关系数均有显著意义（所有患者的 p < 0.0001）。我们的研究是迄今为止最大规模的包括原发肿瘤和转移灶在内的研究，突出了转移灶中 miRNAs 特征的持续存在，并且原发灶似乎是转移灶 miRNA 谱的主要决定因素。
