急性白血病止血并发症的管理：来自 ISTH SSC 的指南。
Management of hemostatic complications in acute leukemia: Guidance from the SSC of the ISTH.
机构信息
Department of Medicine, University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Blood Transfusion Service, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
出版信息
J Thromb Haemost. 2020 Dec;18(12):3174-3183. doi: 10.1111/jth.15074.
Abstract
Patients with acute leukemia frequently develop thrombocytopenia and hemostatic complications caused by coagulopathy. Coagulopathy complicates the management of these patients and can lead to significant morbidity and mortality. This guidance document aims to review and provide guidance on the management of hemostatic complications in adult patients with acute leukemia, addressing four main issues, including platelet transfusion, disseminated intravascular coagulation, L-asparaginase-related hypofibrinogenemia, and the use of antifibrinolytic agents.
摘要
急性白血病患者常因凝血功能障碍而出现血小板减少和止血并发症。凝血功能障碍使这些患者的治疗变得复杂，并可能导致严重的发病率和死亡率。本指导文件旨在回顾和提供成人急性白血病患者止血并发症管理的指导，涉及四个主要问题，包括血小板输注、弥漫性血管内凝血、L-天冬酰胺酶相关的低纤维蛋白原血症以及抗纤维蛋白溶解剂的使用。
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