State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi 330031, People's Republic of China.
Jiangxi Province Key Laboratory of Edible and Medicinal Resources Exploitation, Nanchang University, Nanchang, Jiangxi 330031, People's Republic of China.
J Agric Food Chem. 2021 Aug 18;69(32):9157-9166. doi: 10.1021/acs.jafc.0c07342. Epub 2021 Jan 12.
Medium-chain triglycerides (MCTs) are found in limited foods. In these medium-chain oil resources, the abundance of lauric acid (LA) is the highest among medium-chain fatty acids (MCFAs), and its effects on lipid metabolism in obese rats have not been well-studied. This study aimed to determine the anti-obesity effects and mechanisms of lauric triglyceride (LT) in Sprague Dawley (SD) rats. LA and glycerin were used to synthesize LT, then LT was used to treat obese rats for 12 weeks. The results showed that LT significantly reduced the body weight, body mass index, and Lee's index in obese rats. The mRNA expression levels of the anorexic neuropeptide in the hypothalamus between the LT group and the other groups were not different, while the gene expression levels of the orexigenic neuropeptides and decreased significantly in the LT group. Except serum cholesterol, LT improved the serum triglyceride metabolism in the obese rats and reduced adipocyte and hepatic lipid deposition. Moreover, LT inhibited the expression of lipogenesis-related genes and proteins (SREBP-1c, ACC1, and FASN) and increased the expression of lipolysis (ATGL, HSL, and LPL) and β-oxidation (PPARα, CPT-1a, and PCG-1α) related genes and proteins in the white fat and liver. Furthermore, LT increased the mRNA expression of mitochondrial-biosynthesis-related genes (, , and ) in the liver. The results indicated that LT ameliorates diet-induced obesity in rats.
中链甘油三酯（MCTs）存在于有限的食物中。在这些中链油资源中，月桂酸（LA）在中链脂肪酸（MCFAs）中的含量最高，其对肥胖大鼠脂代谢的影响尚未得到很好的研究。本研究旨在确定月桂酸三酯（LT）在 Sprague Dawley（SD）大鼠中的抗肥胖作用及其机制。LA 和甘油用于合成 LT，然后用 LT 治疗肥胖大鼠 12 周。结果表明，LT 显著降低了肥胖大鼠的体重、体重指数和 Lee 指数。LT 组和其他组之间下丘脑厌食神经肽 的 mRNA 表达水平没有差异，而 LT 组的食欲肽 和 的基因表达水平显著降低。除血清胆固醇外，LT 改善了肥胖大鼠的血清甘油三酯代谢，减少了脂肪细胞和肝脂质沉积。此外，LT 抑制了脂肪生成相关基因和蛋白（SREBP-1c、ACC1 和 FASN）的表达，增加了脂肪分解（ATGL、HSL 和 LPL）和β-氧化（PPARα、CPT-1a 和 PCG-1α）相关基因和蛋白的表达在白色脂肪和肝脏中。此外，LT 增加了肝脏中与线粒体生物合成相关的基因（、和 ）的 mRNA 表达。结果表明 LT 改善了大鼠饮食诱导的肥胖。
