HER2neu 在胃癌中的作用。

Role of HER2neu expression in gastric cancer.

机构信息

Department of Pathology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

出版信息

Indian J Pathol Microbiol. 2021 Jan-Mar;64(1):58-64. doi: 10.4103/IJPM.IJPM_835_19.

DOI:10.4103/IJPM.IJPM_835_19

PMID:33433410

Abstract

BACKGROUND

Gastric cancer is one of the most common cancers in the world and is responsible for over a million deaths. Gastric cancer broadly consists of two main histological types, diffuse and intestinal, and can be further classified as proximal (cardia) and distal (corpus and pylorus) cancers. The presence of Her2neu in certain cancers including gastric cancers has helped in throwing some light on the prediction of prognosis of the tumours. This study was carried out to assess and evaluate the role of Her2neu immunohistochemical expression in gastric cancers.

METHODOLOGY

This study was carried out as a retrospective study on paraffin blocks of 70 gastrectomy specimens in the pathology department of our hospital. After the histological assessment and interpretation of data, appropriate blocks were chosen and sections of 3 micron thickness were cut and immunohistochemical staining of Her2neu was done and scoring was carried out.

RESULTS

We found that gastric cancer occurred predominantly in men as compared to women. Antrum was the most common site involved in gastric cancer (60%). In our study Grade 2 predominated (54%) than Grade 1 (4.2%) and Grade 3 (41%). According to the scoring system of Her2neu expression by immunohistochemistry in gastric cancer it was positive (3+) in 8 cases (11.4%), equivocal (2+) in 10 cases (14.3%) and negative (0+,1+) in 52 cases (74.3%). Her2neu was seen positive 13.7% of intestinal type tumours and in only 5.3% of diffuse type of tumours (P < 0.05).

CONCLUSION

Her2neu testing in gastric adenocarcinomas especially in histologically identified early gastric carcinoma is recommended.

摘要

背景

胃癌是世界上最常见的癌症之一，导致超过 100 万人死亡。胃癌主要包括两种组织学类型，弥漫型和肠型，并且可以进一步分为近端（贲门）和远端（胃体和幽门）癌症。某些癌症（包括胃癌）中 Her2neu 的存在有助于阐明肿瘤预后的预测。本研究旨在评估 Her2neu 免疫组织化学表达在胃癌中的作用。

方法

本研究是在我们医院病理科的 70 例胃切除术标本的石蜡块上进行的回顾性研究。在对数据进行组织学评估和解释后，选择适当的块，并切取 3 微米厚的切片进行 Her2neu 免疫组织化学染色和评分。

结果

我们发现，与女性相比，男性更容易患胃癌。胃窦是胃癌最常见的部位（60%）。在我们的研究中，2 级（54%）多于 1 级（4.2%）和 3 级（41%）。根据 Her2neu 在胃癌中的免疫组织化学表达评分系统，8 例（11.4%）为阳性（3+），10 例（14.3%）为不确定（2+），52 例（74.3%）为阴性（0+，1+）。Her2neu 在肠型肿瘤中的阳性率为 13.7%，而在弥漫型肿瘤中仅为 5.3%（P<0.05）。