Department of Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
Indian J Pathol Microbiol. 2021 Jan-Mar;64(1):174-176. doi: 10.4103/IJPM.IJPM_1006_19.
Adenocarcinoma admixed with neuroendocrine carcinoma of the uterine cervix is a rare malignancy with a poor prognosis. In the literature, there are few reported cases. Herein, we report a case of a 56-year-old Turkish woman with cervical adenocarcinoma admixed with small cell neuroendocrine carcinoma. Histological examination of endocervical curettage specimens revealed a tumor composed of almost equal areas of small cell neuroendocrine carcinoma and adenocarcinoma. Neuroendocrine differentiation was confirmed by immunohistochemistry for chromogranin-A, synaptophysin, and CD 56. After the adenocarcinoma and small cell neuroendocrine carcinoma association was detected in the curettage material, both cervicovaginal smear and then total abdominal hysterectomy and bilateral salpingo-oophorectomy resection material of the patient were submitted to our pathology department. Histological features of both curettage and resection material were determined by immunohistochemical studies.
宫颈混合性腺神经内分泌癌是一种罕见的恶性肿瘤，预后不良。在文献中，仅有少数报道病例。在此，我们报告一例 56 岁土耳其女性宫颈腺癌混合小细胞神经内分泌癌。经宫颈内膜刮除术标本的组织学检查发现，肿瘤几乎由小细胞神经内分泌癌和腺癌等面积组成。免疫组织化学染色显示神经内分泌分化，为嗜铬粒蛋白 A、突触素和 CD56。在刮除物中检测到腺癌和小细胞神经内分泌癌的关联后，我们的病理科还收到了患者宫颈阴道涂片以及随后的全子宫切除术和双侧输卵管卵巢切除术的切除物。通过免疫组织化学研究确定了刮除物和切除物的组织学特征。
