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Targeting transglutaminase 2 as a potential disease modifying therapeutic strategy for synucleinopathies.

作者信息

Zhang Jie, Jasutkar Hilary Grosso, Mouradian M Maral

机构信息

Robert Wood Johnson Medical School Institute for Neurological Therapeutics, and Department of Neurology, Rutgers Biomedical and Health Sciences, Piscataway, NJ, USA.

出版信息

Neural Regen Res. 2021 Aug;16(8):1560-1561. doi: 10.4103/1673-5374.303027.

DOI:10.4103/1673-5374.303027
PMID:33433482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8323704/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/8323704/37f3aa1ddacb/NRR-16-1560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/8323704/37f3aa1ddacb/NRR-16-1560-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/8323704/37f3aa1ddacb/NRR-16-1560-g001.jpg

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本文引用的文献

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2
Evolving Therapy for Celiac Disease.乳糜泻的不断发展的治疗方法。
Front Pediatr. 2019 May 14;7:193. doi: 10.3389/fped.2019.00193. eCollection 2019.
3
Transglutaminase inhibitors: a patent review.转谷氨酰胺酶抑制剂:专利综述
Expert Opin Ther Pat. 2016;26(1):49-63. doi: 10.1517/13543776.2016.1115836. Epub 2015 Nov 24.
4
Transglutaminase 2 exacerbates α-synuclein toxicity in mice and yeast.转谷氨酰胺酶 2 加剧了小鼠和酵母中 α-突触核蛋白的毒性。
FASEB J. 2014 Oct;28(10):4280-91. doi: 10.1096/fj.14-251413. Epub 2014 Jun 26.
5
Transglutaminase inhibition as a possible therapeutical approach to protect cells from death in neurodegenerative diseases.抑制转谷氨酰胺酶作为一种可能的治疗方法,用于保护神经退行性疾病中的细胞免于死亡。
Recent Pat CNS Drug Discov. 2013 Aug;8(2):161-8. doi: 10.2174/15748898113089990001.
6
Transglutaminase 2: biology, relevance to neurodegenerative diseases and therapeutic implications.转谷氨酰胺酶 2:生物学、与神经退行性疾病的相关性及治疗意义。
Pharmacol Ther. 2012 Mar;133(3):392-410. doi: 10.1016/j.pharmthera.2011.12.003. Epub 2011 Dec 22.
7
Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease.酶活性的阻断抑制了帕金森病细胞模型中组织转谷氨酰胺酶介导的α-突触核蛋白的转酰胺反应。
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