Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Department of Prevention and Health Care, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China.
Dig Dis Sci. 2021 Nov;66(11):4008-4016. doi: 10.1007/s10620-020-06732-2. Epub 2021 Jan 12.
The high incidence of osteopathy among patients with chronic pancreatitis (CP) has garnered increased attention over recent years. The aims of this study were to assess the prevalence and risk factors for osteopathy in Chinese patients with CP.
This was a cross-sectional study of CP patients from a large center in China; patients were recruited between 31 January 2017 and 31 January 2018. Bone density and laboratory tests, including bone-related biochemical, inflammatory, and hormone parameters, were assessed prospectively. Differences between patients with and without osteopathy were analyzed. Logistic regression analysis was used to investigate associations between variables.
In total, 104 CP patients were enrolled in this study (68.3% idiopathic and 31.7% alcoholic). According to the M-ANNHEIM classification, 87.5% of the patients were at an early stage (0-II). Osteopenia was diagnosed in 30.8% of patients and osteoporosis in 5.8%; thus, a total of 36.5% of patients presented with osteopathy. In multivariate analysis, the independent risk factors for osteopathy in CP patients were age (OR = 1.04; 95% CI = 1.00-1.08; P = 0.030), BMI (OR = 0.72; 95% CI = 0.58-0.89; P = 0.003), and PTH (OR = 0.96; 95% CI = 0.93-1.00; P = 0.022).
This study is the first to report the prevalence of osteopathy in Chinese patients with CP. It found that age and low BMI are significant risk factors for osteopathy. Low PTH (but within the normal range) showed a weak association with osteopathy, which warrants further exploration.
近年来，慢性胰腺炎（CP）患者中骨病的高发病率引起了越来越多的关注。本研究旨在评估中国 CP 患者中骨病的患病率和危险因素。
这是一项在中国一家大型中心进行的 CP 患者的横断面研究；患者于 2017 年 1 月 31 日至 2018 年 1 月 31 日期间招募。前瞻性评估骨密度和实验室检查，包括骨相关生化、炎症和激素参数。分析了患有和不患有骨病的患者之间的差异。采用逻辑回归分析来研究变量之间的关联。
本研究共纳入 104 例 CP 患者（68.3%为特发性，31.7%为酒精性）。根据 M-ANNHEIM 分类，87.5%的患者处于早期（0-II 期）。30.8%的患者诊断为骨质疏松症，5.8%的患者诊断为骨质疏松症；因此，共有 36.5%的患者存在骨病。多变量分析显示，CP 患者骨病的独立危险因素为年龄（OR=1.04；95%CI=1.00-1.08；P=0.030）、BMI（OR=0.72；95%CI=0.58-0.89；P=0.003）和 PTH（OR=0.96；95%CI=0.93-1.00；P=0.022）。
本研究首次报道了中国 CP 患者骨病的患病率。研究发现，年龄和低 BMI 是骨病的重要危险因素。低 PTH（但在正常范围内）与骨病有微弱关联，值得进一步探讨。
