Department of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Turk J Med Sci. 2021 Jun 28;51(3):1229-1233. doi: 10.3906/sag-2008-18.
BACKGROUND/AIM: Hepatitis B virus (HBV) vaccination rates are insufficient in high-risk patients worldwide. This study aimed to investigate the screening, immunization, and vaccination rates in three high-risk groups for HBV infection: allogeneic hematopoietic stem cell transplantation (AHSCT), renal transplantation (RT), and chronic hepatitis C (CHC) groups.
The serological data of consecutive patients between 2014 and 2019 were reviewed using the hospital database.
The HBV screening rates were 100.0%, 90.4%, and 82.4% in the AHSCT, CHC, and RT groups, respectively (p = 0.003). The immunization rates against HBV through either previous exposure or vaccination were 79.5%, 71.7%, and 46.5% in the AHSCT, RT, and CHC groups, respectively (p < 0.001). The HBV vaccination rate was significantly low in the CHC group (71.5%, 69.0%, 34.6% in the AHSCT, RT, and CHC groups, respectively, p < 0.001). If patients lost their immunity due to immunosuppressive therapy were accounted, the vaccination rates increased to 95.2% in the AHSCT group and 72.9% in the RT group. The rate of annual screening for HBV status was 97.9% in the AHSCT group, but it was only 23.9% in the RT group.
HBV screening and vaccination rates were significantly lower in the RT and CHC groups than in the AHSCT group.
背景/目的：乙型肝炎病毒 (HBV) 疫苗接种率在全球高危人群中仍然不足。本研究旨在调查三种乙型肝炎病毒感染高危人群（异基因造血干细胞移植 (AHSCT)、肾移植 (RT) 和慢性丙型肝炎 (CHC) 组）的筛查、免疫和疫苗接种率。
使用医院数据库回顾了 2014 年至 2019 年连续患者的血清学数据。
AHSCT、CHC 和 RT 组的 HBV 筛查率分别为 100.0%、90.4%和 82.4%（p = 0.003）。通过既往暴露或接种疫苗获得的 HBV 免疫率分别为 AHSCT、RT 和 CHC 组的 79.5%、71.7%和 46.5%（p < 0.001）。CHC 组的 HBV 疫苗接种率明显较低（AHSCT、RT 和 CHC 组分别为 71.5%、69.0%和 34.6%，p < 0.001）。如果考虑因免疫抑制治疗而丧失免疫力的患者，AHSCT 组的疫苗接种率增加到 95.2%，RT 组增加到 72.9%。AHSCT 组每年筛查 HBV 状态的比例为 97.9%，而 RT 组仅为 23.9%。
与 AHSCT 组相比，RT 和 CHC 组的 HBV 筛查和疫苗接种率明显较低。
