从杰出应答者研究中得到的启示。

Lessons from the Study of Exceptional Responders.

机构信息

Department of Pharmacology, Weill Cornell Medicine Graduate School of Medical Sciences, New York City, NY, USA; Memorial Sloan Kettering Cancer Center, New York City, NY, USA.

Department of Medicine, Weill Cornell Medical College, New York City, NY, USA; Memorial Sloan Kettering Cancer Center, New York City, NY, USA.

出版信息

Cancer Cell. 2021 Jan 11;39(1):11-13. doi: 10.1016/j.ccell.2020.11.008.

DOI:10.1016/j.ccell.2020.11.008

PMID:33434508

Abstract

In this issue of Cancer Cell, Wheeler et al. report that mechanisms of exceptional response to cancer treatment can be grouped into four broad categories: dysregulated intracellular signaling pathways, altered DNA damage response, tumor microenvironment or immune engagement, and alterations associated with a favorable prognosis.

摘要

本期《癌细胞》杂志上，Wheeler 等人报告称，对癌症治疗有极好反应的机制可以分为四大类：细胞内信号通路失调、DNA 损伤反应改变、肿瘤微环境或免疫激活，以及与预后良好相关的改变。