基质 WNT 使肿瘤保持低温并促进转移。

Stromal WNTer Keeps the Tumor Cold and Drives Metastasis.

机构信息

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany; Division of Cancer Progression and Metastasis, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Beatson Institute for Cancer Research, Glasgow G61 1BD, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

出版信息

Dev Cell. 2021 Jan 11;56(1):3-4. doi: 10.1016/j.devcel.2020.12.011.

DOI:10.1016/j.devcel.2020.12.011

PMID:33434524

Abstract

Carcinoma-associated fibroblast (CAF) infiltration confers poor clinical outcomes in colorectal cancer (CRC) through mechanisms that are still unclear. In this issue of Developmental Cell, Kasashima et al. report that loss of PKCζ engenders a SOX2/SFRP2-positive CAF subpopulation that increases CRC aggressiveness by creating an immunosuppressed environment.

摘要

癌相关成纤维细胞（CAF）浸润通过尚不清楚的机制导致结直肠癌（CRC）患者的临床预后不良。在本期《发育细胞》中，Kasashima 等人报道称，蛋白激酶 Cζ（PKCζ）缺失会产生 SOX2/SFRP2 阳性的 CAF 亚群，通过创造免疫抑制环境增加 CRC 的侵袭性。