Gransden W R, Wickstead M, Eykyn S J
Department of Microbiology, St. Thomas's Hospital Medical School, London.
J Laryngol Otol. 1988 Jan;102(1):33-6. doi: 10.1017/s0022215100103895.
Between 1974 and 1986, eleven of 114 patients undergoing trans-sphenoidal removal of pituitary tumours developed meningitis despite prophylaxis, usually with chloramphenicol. Nine patients had cerebrospinal fluid rhinorrhoea and one died. A variety of pathogens was isolated, including enterobacteria, and four of the eleven were resistant to the antibiotics given as prophylaxis. Enterobacterial meningitis was always associated with infection of the sphenoidal sinus involving the muscle graft or nasal pack (five cases), and removal of the muscle graft was necessary in three cases despite the use of appropriate antibiotics.
1974年至1986年间，114例接受经蝶窦垂体瘤切除术的患者中，有11例尽管接受了预防性治疗（通常使用氯霉素）仍发生了脑膜炎。9例患者出现脑脊液鼻漏，1例死亡。分离出了多种病原体，包括肠杆菌，11例中有4例对预防性使用的抗生素耐药。肠杆菌性脑膜炎总是与蝶窦感染有关，累及肌瓣或鼻腔填塞物（5例），尽管使用了适当的抗生素，但3例仍需要切除肌瓣。
