Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME, 04074, USA.
Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, 04496, USA.
Cell Commun Signal. 2021 Jan 12;19(1):6. doi: 10.1186/s12964-020-00695-7.
Interleukin-17 receptor D (IL17RD or IL-17RD) also known as Sef (similar expression to fibroblast growth factor), is a single pass transmembrane protein that is reported to regulate several signaling pathways . IL17RD was initially described as a feedback inhibitor of fibroblast growth factor (FGF) signaling during zebrafish and frog development. It was subsequently determined to regulate other receptor tyrosine kinase signaling cascades as well as several proinflammatory signaling pathways including Interleukin-17A (IL17A), Toll-like receptors (TLR) and Interleukin-1α (IL1α) in several vertebrate species including humans. This review will provide an overview of IL17RD regulation of signaling pathways and functions with emphasis on regulation of development and pathobiological conditions. We will also discuss gaps in our knowledge about IL17RD function to provide insight into opportunities for future investigation. Video Abstract.
白细胞介素 17 受体 D（IL17RD 或 IL-17RD），也称为 Sef（与成纤维细胞生长因子相似的表达），是一种单次跨膜蛋白，据报道可调节几种信号通路。IL17RD 最初被描述为斑马鱼和青蛙发育过程中成纤维细胞生长因子（FGF）信号的反馈抑制剂。随后，它被确定可调节其他受体酪氨酸激酶信号级联以及几种促炎信号通路，包括白细胞介素 17A（IL17A）、Toll 样受体（TLR）和白细胞介素 1α（IL1α），在包括人类在内的几种脊椎动物物种中。本综述将概述 IL17RD 对信号通路和功能的调节，重点介绍其对发育和病理生理状况的调节。我们还将讨论关于 IL17RD 功能的知识空白，为未来的研究提供见解。视频摘要。
