Department of Cellular Biology and Histology, School of Medicine and Nursing, University of the Basque Country, 48940, Leioa, Bizkaia, Spain.
Catalysis S.L., Toledo, Spain.
Int J Med Sci. 2021 Jan 1;18(3):835-845. doi: 10.7150/ijms.50122. eCollection 2021.
Chemotherapy and radiotherapy are the most frequent treatment for patients suffering from malignant progression of cancer. Even though new treatments are now being implemented, administration of these chemotherapeutic agents remains as the first line option in many tumor types. However, the secondary effects of these compounds represent one of the main reasons cancer patients lose life quality during disease progression. Recent data suggests that Ocoxin, a plant extract and natural compound based nutritional complement rich in antioxidants and anti-inflammatory mediators exerts a positive effect in patients receiving chemotherapy and radiotherapy. This mixture attenuates the chemotherapy and radiotherapy-related side effects such as radiation-induced skin burns and mucositis, chemotherapy-related diarrhea, hepatic toxicity and blood-infection. Moreover, it has been proven to be effective as anticancer agent in different tumor models both and , potentiating the cytotoxic effect of several chemotherapy compounds such as Lapatinib, Gemcitabine, Paclitaxel, Sorafenib and Irinotecan. The aim of this review is to put some light on the potential of this nutritional mixture as an anticancer agent and complement for the standard chemotherapy routine.
化疗和放疗是癌症恶性进展患者最常见的治疗方法。尽管现在正在实施新的治疗方法，但在许多肿瘤类型中，这些化疗药物的给药仍然是首选。然而，这些化合物的次要作用是癌症患者在疾病进展过程中失去生活质量的主要原因之一。最近的数据表明，Ocoxin 是一种植物提取物和天然化合物的营养补充剂，富含抗氧化剂和抗炎介质，对接受化疗和放疗的患者有积极作用。这种混合物减轻了化疗和放疗相关的副作用，如放射性皮肤灼伤和黏膜炎、化疗相关性腹泻、肝毒性和血液感染。此外，它已被证明在不同的肿瘤模型中作为抗癌药物是有效的，增强了几种化疗药物如拉帕替尼、吉西他滨、紫杉醇、索拉非尼和伊立替康的细胞毒性作用。本综述的目的是阐明这种营养混合物作为抗癌药物和标准化疗常规的补充剂的潜力。
