Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Lab Med. 2021 Jul 1;52(4):329-337. doi: 10.1093/labmed/lmaa108.
To investigate the benefits and challenges of introducing next generation chemistry and coagulation automation.
We replaced the Roche modular preanalytic system attached to Roche Cobas 6000 analyzers with the Roche 8100 preanalytical line attached to the Roche Cobas 8000 and Stago STA R Max analyzers. The system included 2 add-on buffers (AOBs) for automated specimen archival and retrieval and primary-tube specimen processing. We measured turnaround time (TAT) from specimen receipt to result for chemistry and coagulation tests before, during, and after system implementation. TAT for add-on tests was also measured.
We completed the system implementation during a 17-month period using existing laboratory space. The TAT for chemistry, coagulation, and add-on tests decreased significantly (P <.005, P <.001, and P <.005, respectively). We encountered several challenges, including barcode-label errors, mechanical problems, and workflow issues due to lack of bidirectional track for coagulation testing.
Next generation laboratory automation yielded significantly shortened and less-variable TAT, particularly for add-on testing. Our approach could help other laboratories in the process of implementing and configuring automated systems.
探讨引入下一代化学和凝血自动化的益处和挑战。
我们用罗氏 8100 前处理系统取代了罗氏 Cobas 6000 分析仪上的罗氏模块化前处理系统,并将其与罗氏 Cobas 8000 和 Stago STA R Max 分析仪相连。该系统包括 2 个附加缓冲液(AOB),用于自动化标本存档和检索以及原始管标本处理。在系统实施之前、期间和之后,我们测量了化学和凝血测试的周转时间(TAT),从收到标本到得出结果。还测量了附加测试的 TAT。
我们使用现有的实验室空间在 17 个月内完成了系统实施。化学、凝血和附加测试的 TAT 显著缩短(P <.005,P <.001 和 P <.005,分别)。我们遇到了一些挑战,包括条形码标签错误、机械问题以及由于缺乏双向凝血测试跟踪而导致的工作流程问题。
下一代实验室自动化显著缩短了 TAT,尤其是附加测试的 TAT,且 TAT 变化更小。我们的方法可以帮助其他实验室在自动化系统的实施和配置过程中。