Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Cell Tissue Res. 2021 Apr;384(1):13-23. doi: 10.1007/s00441-020-03406-3. Epub 2021 Jan 13.
Organ preservation is a prerequisite for an urgent increase in the availability of organs for solid organ transplantation (SOT). An increasing amount of expanded criteria donor (ECD) organs are used clinically. Currently, the paradigm of organ preservation is shifting from simple reduction of cellular metabolic activity to maximal simulation of an ex vivo physiological microenvironment. An ideal organ preservation technique should not only preserve isolated organs but also offer the possibility of rehabilitation and evaluation of organ function prior to transplantation. Based on the fact that mesenchymal stromal cells (MSCs) possess strong regeneration properties, the combination of MSCs with machine perfusion (MP) is expected to be superior to conventional preservation methods. In recent years, several studies have attempted to use this strategy for SOT showing promising outcomes. With better organ function during ex vivo preservation and the potential of utilization of organs previously deemed untransplantable, this strategy is meaningful for patients with organ failure to help overcome organ shortage in the field of SOT.
器官保存是增加用于实体器官移植 (SOT) 的器官可用性的前提条件。越来越多的扩展标准供体 (ECD) 器官被临床使用。目前，器官保存的模式正在从简单地降低细胞代谢活性转变为最大限度地模拟体外生理微环境。理想的器官保存技术不仅应能保存分离的器官，而且还应能在移植前提供器官功能康复和评估的可能性。基于间充质基质细胞 (MSCs) 具有强大的再生特性这一事实，预计将 MSCs 与机器灌注 (MP) 相结合将优于传统的保存方法。近年来，多项研究试图将该策略用于 SOT，结果令人鼓舞。这种策略具有意义，因为它可以改善器官在体外保存期间的功能，并且有可能利用以前被认为不可移植的器官，这有助于解决 SOT 领域的器官短缺问题，帮助器官衰竭患者克服器官短缺问题。
