Salvadori D M, Ribeiro L R, Pereira C A, Beçak W
Serviço de Genética, Instituto Butantan, São Paulo, Brasil.
Mutat Res. 1988 Feb;204(2):283-7. doi: 10.1016/0165-1218(88)90101-2.
Male mice dermally exposed to single or multiple treatment (5 days/2 weeks) showed that the ability of malathion to induce chromosome aberrations in somatic (bone marrow) and germ cells (primary spermatocytes) was related to the type of treatment and dose used. Statistically significant increases of chromosome aberrations in bone marrow cells occurred after single treatment (500 and 2000 mg/kg body wt) when chromatid gaps were included and after multiple treatment (250 and 500 mg/kg) when they were excluded. No dose-response relationships were observed for either treatment. In germ cells, malathion induced a significant increase of univalents in both types of treatment but structural chromosome aberrations were induced only by multiple treatment. Malathion induced a significant decrease of the mitotic indices in the bone marrow.
对雄性小鼠进行单次或多次（5天/2周）皮肤暴露实验，结果表明，马拉硫磷诱导体细胞（骨髓）和生殖细胞（初级精母细胞）染色体畸变的能力与处理类型和所用剂量有关。单次处理（500和2000毫克/千克体重）后，若计入染色单体间隙，骨髓细胞中的染色体畸变有统计学意义的增加；多次处理（250和500毫克/千克）后，若不计入染色单体间隙，则染色体畸变有统计学意义的增加。两种处理均未观察到剂量反应关系。在生殖细胞中，两种处理方式下马拉硫磷均诱导单价体显著增加，但仅多次处理诱导了染色体结构畸变。马拉硫磷使骨髓中的有丝分裂指数显著降低。
