Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada.
Program in Genetics and Molecular Biology, Federal University of Pará, Belém, Brazil.
Sci Rep. 2021 Jan 13;11(1):1007. doi: 10.1038/s41598-020-80389-9.
We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil.
我们评估了三个 PGx 面板来估计生物地理起源的性能：DMET 面板，以及文献中描述的 VIP 和 Preemptive PGx 面板。我们的分析表明，这三个面板很好地捕捉了美洲各地最近混合人群中混合比例的个体变异，Preemptive PGx 和 DMET 面板的表现优于 VIP 面板。我们表明，这些面板提供了有关生物地理起源的可靠信息，并可用于指导 PGx 临床决策支持（CDS）工具的实施。我们还报告说，使用这些面板可以控制最近混合人群中关联研究的群体分层效应，例如在巴西样本中进行的华法林剂量 GWAS 研究。
